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Literature DB >> 16558044

Rabbit arthritis induced by cell-free extracts of erysipelothrix.

Abstract

A cell-free crude extract of Erysipelothrix rhusiopathiae injected intravenously in rabbits induced pathological lesions of the synovial tissue similar to the lesions seen in rheumatoid arthritis. Fluorescence techniques utilizing tagged specific antiserum and fluorescent-tagged antigen injected into nonsensitized rabbits demonstrated the localization of antigen exclusively in the synovium. Localized concentration of fluorescence was demonstrated as early as 1 hr after injection, before histological changes were apparent. After 48 hr, the fluorescence was concentrated in focal areas and early pathological changes characterized as "mesenchymal activation" were observed. A consideration of the significant role of exogenous antigen in the sensitivity arthritides is discussed.

Entities: Disease Species

Year: 1971 PMID： 16558044 PMCID： PMC416227 DOI： 10.1128/iai.3.6.715-722.1971

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

11 in total

1. THE ANTIGENIC COMPONENTS OF ERYSIPELOTHRIX RHUSIOPATHIAE. 3. PURIFICATION OF B- AND C-ANTIGENS.

Authors: G A KALF; M A GRECE
Journal: Arch Biochem Biophys Date: 1964-07 Impact factor: 4.013

2. PASSIVE TRANSFER OF ADJUVANT ARTHRITIS IN RATS WITH LIVING LYMPHOID CELLS OF SENSITIZED DONORS.

Authors: B H WAKSMAN; C WENNERSTEN
Journal: Int Arch Allergy Appl Immunol Date: 1963

3. The antigenic components of Erysipelothrix rhusiopathiae. I. Isolation and serological identification.

Authors: T G WHITE; G F KALF
Journal: Arch Biochem Biophys Date: 1961-12 Impact factor: 4.013

4. The production of arthritis in rabbits by an immunological reaction to fibrin.

Authors: D C DUMONDE; L E GLYNN
Journal: Br J Exp Pathol Date: 1962-08

5. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

6. Association of experimental chronic arthritis with the persistence of group A streptococcal cell walls in the articular tissue.

Authors: J H Schwab; W J Cromartie; S H Ohanian; J G Craddock
Journal: J Bacteriol Date: 1967-11 Impact factor: 3.490

7. Erysipelothrix arthritis in swine: bacteriologic and immunopathologic aspects.

Authors: J F Timoney; D T Berman
Journal: Am J Vet Res Date: 1970-08 Impact factor: 1.156

8. Persistence of group A streptococci labeled with fluorescein isothiocyanate in inflammatory sites in the heart and muscle of mice and rabbits.

Authors: N Rickles; Z Zilberstein; S Kraus; G Arad; M Kaufstein; I Ginsburg
Journal: Proc Soc Exp Biol Med Date: 1969-06

2. New models of chronic synovitis in rabbits induced by mycoplasmas: microbiological, histopathological, and immunological observations on rabbits injected with Mycoplasma arthritidis and Mycoplasma pulmonis.

Authors: B C Cole; M M Griffiths; E J Eichwald; J R Ward
Journal: Infect Immun Date: 1977-04 Impact factor: 3.441

Review 3. Erysipelothrix arthritis in pigs as a comparative model for rheumatoid arthritis.

Authors: R A Drew
Journal: Proc R Soc Med Date: 1972-11

4. The protection of mice by a specific anti-Erysipelothrix insidiosa-neuraminidase-antiserum against Erysipelothrix insidiosa infection.

Authors: H E Müller
Journal: Med Microbiol Immunol Date: 1974-06-19 Impact factor: 3.402

5. Pathogenesis of Salmonella-associated arithritis in the rat.

Authors: A Volkman; F M Collins
Journal: Infect Immun Date: 1975-02 Impact factor: 3.441

5 in total