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Literature DB >> 13859099

The induction of a rheumatoid factor-like substance in rabbits.

Abstract

Hyperimmunization of two groups of rabbits with killed Escherichia coli and Bacillus subtilis has resulted in the formation of a serum factor (RFLS) which resembled the human rheumatoid factor. It was a heat-stable protein that migrated electrophoretically in the gamma-beta globulin range and sedimented rapidly with ultracentrifugation. The serologic properties of the RFLS were destroyed by mercaptoethanol. It reacted primarily with rabbit gamma globulin in an aggregated state (immune complexes or physically aggregated gamma globulin) and demonstrated cross-reactivity with human gamma globulin.

Entities: Chemical Disease Species

Keywords: ANTIGEN-ANTIBODY REACTIONS/experimental

Mesh：

Substances：

Year: 1961 PMID： 13859099 PMCID： PMC2180373 DOI： 10.1084/jem.114.5.791

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

26 in total

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Journal: Science Date: 1957-03-29 Impact factor: 47.728

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Authors: H G KUNKEL; H J SIMON; H FUDENBERG
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8. Differences in the antigenic components of sera of individual rabbits as shown by induced isoprecipitins.

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46 in total

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