Literature DB >> 16557770

Polymorphonuclear leukocyte chemotactic activity in rabbit serum and Guinea pig serum treated with immune complexes: evidence for c5a as the major chemotactic factor.

R Snyderman1, J Phillips, S E Mergenhagen.   

Abstract

A number of polymorphonuclear leukocyte (PMN) chemotactic factors derived from complement components have been described. We sought to determine which of these factors accounted for the majority of PMN chemotactic activity in rabbit serum and guinea pig serum treated with preformed immune complexes. Normal rabbit sera, guinea pig sera, or rabbit sera deficient in C6 were treated with homologous antibovine serum-albumin-bovine serum-albumin complexes. Sera so treated contained one major PMN chemotactic factor which was heat-stable (56 C for 30 min), had a molecular weight of approximately 15,000, and did not require the presence of C6 for its generation. This factor appears to be analogous to C5a.

Entities:  

Year:  1970        PMID： 16557770      PMCID： PMC415936          DOI： 10.1128/iai.1.6.521-525.1970

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  17 in total

1.  Further studies on the chemotactic factor of complement and its formation in vivo.

Authors:  P A Ward; C G Cochrane; H J Muller-Eberhard
Journal:  Immunology       Date:  1966-08       Impact factor: 7.397

2.  Macrophage and neutrophil specific chemotactic factors in serum.

Authors:  P C Wilkinson; J F Borel; V J Stecher-Levin; E Sorkin
Journal:  Nature       Date:  1969-04-19       Impact factor: 49.962

3.  Reaction of a cobra venom factor with guinea pig complement and generation of an activity chemotactic for polymorphonuclear leukocytes.

Authors:  H S Shin; H Gewurz; R Snyderman
Journal:  Proc Soc Exp Biol Med       Date:  1969-05

4.  Studies on chemotaxis. XII. Generation of chemotactic activity for polymorphonuclear leucocytes in sera with complement dificiencies.

Authors:  V J Stecher; E Sorkin
Journal:  Immunology       Date:  1969-02       Impact factor: 7.397

5.  A neutrophil chemotactic factor from human C'5.

Authors:  P A Ward; L J Newman
Journal:  J Immunol       Date:  1969-01       Impact factor: 5.422

6.  Interactions of the complement system with endotoxic lipopolysaccharide. Generation of a factor chemotactic for polymorphonuclear leukocytes.

Authors:  R Snyderman; H Gewurz; S E Mergenhagen
Journal:  J Exp Med       Date:  1968-08-01       Impact factor: 14.307

7.  The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes.

Authors:  S BOYDEN
Journal:  J Exp Med       Date:  1962-03-01       Impact factor: 14.307

8.  Deficiency of the sixth component of complement in rabbits with an inherited complement defect.

Authors:  K Rother; U Rother; H J Müller-Eberhard; J R Nilsson
Journal:  J Exp Med       Date:  1966-10-01       Impact factor: 14.307

9.  Isolation of a fragment (C3a) of the third component of human complement containing anaphylatoxin and chemotactic activity and description of an anaphylatoxin inactivator of human serum.

Authors:  V A Bokisch; H J Müller-Eberhard; C G Cochrane
Journal:  J Exp Med       Date:  1969-05-01       Impact factor: 14.307

10.  THE ROLE OF SERUM COMPLEMENT IN CHEMOTAXIS OF LEUKOCYTES IN VITRO.

Authors:  P A WARD; C G COCHRANE; H J MUELLER-EBERHARD
Journal:  J Exp Med       Date:  1965-08-01       Impact factor: 14.307
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  47 in total

1.  Leukocyte migration in synovial tissue. Leukocyte distribution, orientation, and migratory pattern after immune complex deposition in rabbit knee joints.

Authors:  P Thomsen; L E Ericson
Journal:  Am J Pathol       Date:  1989-06       Impact factor: 4.307

2.  Polymorphonuclear neutrophil chemotaxis under aerobic and anaerobic conditions.

Authors:  D A Casciato; L S Goldberg; R Bluestone
Journal:  Infect Immun       Date:  1978-08       Impact factor: 3.441

Review 3.  Chemotaxis and its significance for leucocyte accumulation.

Authors:  H U Keller
Journal:  Agents Actions       Date:  1972-06

4.  A comparison between the active cutaneous Arthus reaction and immune-mediated enteroluminal neutrophil emigration in pigs.

Authors:  J E Bellamy; N O Nielsen
Journal:  Can J Comp Med       Date:  1974-04

5.  N-formylmethionyl peptides as chemoattractants for leucocytes.

Authors:  E Schiffmann; B A Corcoran; S M Wahl
Journal:  Proc Natl Acad Sci U S A       Date:  1975-03       Impact factor: 11.205

6.  Role for endotoxin in the leukocyte infiltration accompanying Escherichia coli inflammation.

Authors:  A C Issekutz; S Bhimji
Journal:  Infect Immun       Date:  1982-05       Impact factor: 3.441

7.  Receptor-mediated activation of a phospholipase A2 in rabbit neutrophil plasma membrane.

Authors:  B J Bormann; C K Huang; W M Mackin; E L Becker
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

8.  Mechanisms of neutrophil accumulation in the lungs of patients with idiopathic pulmonary fibrosis.

Authors:  G W Hunninghake; J E Gadek; T J Lawley; R G Crystal
Journal:  J Clin Invest       Date:  1981-07       Impact factor: 14.808

9.  Polymorphonuclear leukocyte activation by a synthetic muramyl dipeptide analog.

Authors:  Y Osada; T Otani; M Sato; T Une; K Matsumoto; H Ogawa
Journal:  Infect Immun       Date:  1982-12       Impact factor: 3.441

10.  Stimulation of granulation tissue formation by platelet-derived growth factor in normal and diabetic rats.

Authors:  G R Grotendorst; G R Martin; D Pencev; J Sodek; A K Harvey
Journal:  J Clin Invest       Date:  1985-12       Impact factor: 14.808
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