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Literature DB >> 13872176

The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes.

Abstract

An in vitro technique is described for assessing the chemotactic activity of soluble substances on motile cells. Antibody-antigen mixtures when incubated (37 degrees C) in medium containing fresh (i.e. non-inactivated) normal rabbit serum exert a strong chemotactic effect on rabbit polymorphonuclear leucocytes. Results are described which indicate that, when antibody-antigen complexes are incubated (37 degrees C) in fresh serum, a heat-stable (56 degrees C) substance (or substances) is produced which acts directly as a chemotactic stimulus on the polymorphs. This heat-stable chemotactic substance is not produced when antibody-antigen complexes are incubated in serum which has been heated at 56 degrees C for 30 minutes.

Entities: Species

Keywords: ANTIBODIES; ANTIGENS; LEUKOCYTES/chemistry

Mesh：

Substances：

Year: 1962 PMID： 13872176 PMCID： PMC2137509 DOI： 10.1084/jem.115.3.453

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

4 in total

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Authors: R J PULVERTAFT
Journal: Proc R Soc Med Date: 1959-05

2. Studies on mouse lymphomas. II. Behavior of three lymphomas in diffusion chambers in relation to their invasive capacity in the host.

Authors: E SHELTON; M E RICH
Journal: J Natl Cancer Inst Date: 1958-07 Impact factor: 13.506

3. Role of chemotaxis in inflammation.

Authors: H HARRIS
Journal: Physiol Rev Date: 1954-07 Impact factor: 37.312

4. Studies of phagocytosis of group A streptococci by polymorphonuclear leucocytes in vitro.

Authors: J G HIRSCH; A B CHURCH
Journal: J Exp Med Date: 1960-03-01 Impact factor: 14.307

4 in total

667 in total

1. Enhanced chemotaxis of macrophages by strenuous exercise in trained mice: thyroid hormones as possible mediators.

Authors: E Ortega; M A Forner; J J Garcia; A B Rodriguez; C Barriga
Journal: Mol Cell Biochem Date: 1999-11 Impact factor: 3.396

Review 2. Factors influencing airway inflammation in chronic obstructive pulmonary disease.

Authors: A Hill; S Gompertz; R Stockley
Journal: Thorax Date: 2000-11 Impact factor: 9.139

3. Comparison of leukocyte count and function in smoking and nonsmoking young men.

Authors: R C Noble; B B Penny
Journal: Infect Immun Date: 1975-09 Impact factor: 3.441

4. Reversible granulocyte killing defect in anorexia nervosa.

Authors: F M Gotch; C J Spry; A G Mowat; P B Beeson; I C Maclennan
Journal: Clin Exp Immunol Date: 1975-08 Impact factor: 4.330

5. Suppression of leukocyte chemotaxis in vitro by chemotherapeutic agents used in the management of thermal injuries.

Authors: G D Warden; A D Mason; B A Pruitt
Journal: Ann Surg Date: 1975-03 Impact factor: 12.969

6. [Granulocyte dysfunction. Part II. Secondary defects. (authors transl)].

Authors: D Niethammer; A Wildfeuer; E Kleihauer; O Haferkamp
Journal: Klin Wochenschr Date: 1975-08-15

7. [The chemotactic effect of blister roof, blister fluid and blister floor on polymorphonuclear leucocytes in dermatitis herpetiformis Duhring (author's transl)].

Authors: K Bork
Journal: Arch Dermatol Forsch Date: 1975