Literature DB >> 1654586

A murine model for studying EHV-1-induced abortion.

A R Awan1, J S Gibson, H J Field.   

Abstract

Balb/c mice were infected with two abortigenic strains of equine herpesvirus-1 (EHV-1) by intranasal inoculation. The inoculation of one strain produced subclinical disease while the other produced a disease characterised by weight loss, constitutional signs, and death in the most severely affected animals. When pregnant mice were infected by the same method of inoculation, one strain of virus produced premature parturition; both strains produced fetal abnormalities. In some cases, virus could be detected in the aborted fetuses by means of virus isolation and immunofluorescent staining.

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Year:  1991        PMID： 1654586     DOI： 10.1016/0034-5288(91)90038-p

Source DB:  PubMed          Journal:  Res Vet Sci        ISSN： 0034-5288            Impact factor:   2.534


  5 in total

1.  Immunization with Attenuated Equine Herpesvirus 1 Strain KyA Induces Innate Immune Responses That Protect Mice from Lethal Challenge.

Authors:  Seong K Kim; Akhalesh K Shakya; Dennis J O'Callaghan
Journal:  J Virol       Date:  2016-08-26       Impact factor: 5.103

2.  Characterization of the cytolytic T-lymphocyte response to a candidate vaccine strain of equine herpesvirus 1 in CBA mice.

Authors:  P M Smith; Y Zhang; S R Jennings; D J O'Callaghan
Journal:  J Virol       Date:  1998-07       Impact factor: 5.103

3.  Effects of phosphonylmethoxyalkyl derivatives studied with a murine model for abortion induced by equine herpesvirus 1.

Authors:  A R Awan; H J Field
Journal:  Antimicrob Agents Chemother       Date:  1993-11       Impact factor: 5.191

4.  Reinfection and reactivation of equine herpesvirus-1 in the mouse.

Authors:  H J Field; A R Awan; R de la Fuente
Journal:  Arch Virol       Date:  1992       Impact factor: 2.574

5.  Immunization with glycoprotein C of equine herpesvirus-1 is associated with accelerated virus clearance in a murine model.

Authors:  D Tewari; S V Nair; M C De Ungria; G L Lawrence; M Hayden; D N Love; H J Field; J M Whalley
Journal:  Arch Virol       Date:  1995       Impact factor: 2.574
  5 in total

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