Literature DB >> 8285638

Effects of phosphonylmethoxyalkyl derivatives studied with a murine model for abortion induced by equine herpesvirus 1.

A R Awan1, H J Field.   

Abstract

(S)-9-(3-Hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) were tested in a mouse model for equine herpesvirus 1-induced abortion. HPMPA, given twice daily, reduced virus replication, but the compound was embryotoxic. A single dose of HPMPC, however, reduced the incidence of abortion and transfer of virus to the fetuses while producing no obvious toxic effects.

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Year:  1993        PMID： 8285638      PMCID： PMC192413          DOI： 10.1128/AAC.37.11.2478

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

1.  Granulated metrial gland cells in the mouse placenta.

Authors:  I J Stewart
Journal:  Placenta       Date:  1990 May-Jun       Impact factor: 3.481

2.  Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo.

Authors:  E De Clercq; A Holý; I Rosenberg
Journal:  Antimicrob Agents Chemother       Date:  1989-02       Impact factor: 5.191

3.  A novel selective broad-spectrum anti-DNA virus agent.

Authors:  E De Clercq; A Holý; I Rosenberg; T Sakuma; J Balzarini; P C Maudgal
Journal:  Nature       Date:  1986 Oct 2-8       Impact factor: 49.962

4.  Studies on equine herpesviruses. 3. The incidence in Queensland of three different equine herpesvirus infections.

Authors:  T J Bagust; R R Pascoe; T J Harden
Journal:  Aust Vet J       Date:  1972-02       Impact factor: 1.281

Review 5.  Molecular epizootiology, pathogenesis, and prophylaxis of equine herpesvirus-1 infections.

Authors:  G P Allen; J T Bryans
Journal:  Prog Vet Microbiol Immunol       Date:  1986

6.  Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine in various models of herpes simplex virus infection in mice.

Authors:  E De Clercq; A Holý
Journal:  Antimicrob Agents Chemother       Date:  1991-04       Impact factor: 5.191

7.  Effective chemotherapy of equine herpesvirus 1 by phosphonylmethoxyalkyl derivatives of adenine demonstrated in a novel murine model for the disease.

Authors:  H J Field; A R Awan
Journal:  Antimicrob Agents Chemother       Date:  1990-05       Impact factor: 5.191

8.  The activity of (S)-1-[(3-hydroxy-2-phosphonyl methoxy) propyl] cytosine (HPMPC) against equine herpesvirus-1 (EHV-1) in cell cultures, mice and horses.

Authors:  J S Gibson; J D Slater; H J Field
Journal:  Antiviral Res       Date:  1992-09       Impact factor: 5.970

9.  Antiviral activity of arabinosylthymine in herpesviral replication: mechanism of action in vivo and in vitro.

Authors:  J F Aswell; G P Allen; A T Jamieson; D E Campbell; G A Gentry
Journal:  Antimicrob Agents Chemother       Date:  1977-08       Impact factor: 5.191

10.  Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines.

Authors:  E De Clercq; T Sakuma; M Baba; R Pauwels; J Balzarini; I Rosenberg; A Holý
Journal:  Antiviral Res       Date:  1987-12       Impact factor: 5.970
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  1 in total

1.  Antivaccinia activities of acyclic nucleoside phosphonate derivatives in epithelial cells and organotypic cultures.

Authors:  R Snoeck; A Holý; C Dewolf-Peeters; J Van Den Oord; E De Clercq; G Andrei
Journal:  Antimicrob Agents Chemother       Date:  2002-11       Impact factor: 5.191
  1 in total

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