Literature DB >> 7794119

Immunization with glycoprotein C of equine herpesvirus-1 is associated with accelerated virus clearance in a murine model.

D Tewari1, S V Nair, M C De Ungria, G L Lawrence, M Hayden, D N Love, H J Field, J M Whalley.   

Abstract

The glycoprotein C (gC) gene of equine herpesvirus-1 (EHV-1) was expressed in insect cells by a recombinant baculovirus as several products with apparent molecular weights of 66 kDa-80 kDa. The baculovirus EHV-1 gC products were recognised by monoclonal antibody and by EHV-1 convalescent equine sera, indicating conservation of antigenic determinants and confirming this glycoprotein as a target for the equine immune system. Mice immunized with recombinant EHV-1 gC showed accelerated clearance of EHV-1 from respiratory tissues following intranasal challenge. Virus clearance was accompanied by virus specific antibodies and by cell mediated immune responses measured by a delayed type hypersensitivity reaction and lymphocyte stimulation by killed EHV-1 as antigen.

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Year:  1995        PMID： 7794119     DOI： 10.1007/bf01309967

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  23 in total

1.  Coexpression by vaccinia virus recombinants of equine herpesvirus 1 glycoproteins gp13 and gp14 results in potentiated immunity.

Authors:  P X Guo; S Goebel; M E Perkus; J Taylor; E Norton; G Allen; B Languet; P Desmettre; E Paoletti
Journal:  J Virol       Date:  1990-05       Impact factor: 5.103

2.  Studies on glycoprotein 13 (gp13) of equid herpesvirus 1 using affinity-purified gp13, glycoprotein-specific monoclonal antibodies and synthetic peptides in a hamster model.

Authors:  A Stokes; A H Corteyn; L A Pullen; T R Doel; D M Meredith; R A Killington; I W Halliburton; G R Whittaker; L A Wheldon; L Nicolson
Journal:  J Gen Virol       Date:  1991-04       Impact factor: 3.891

3.  Expression in recombinant vaccinia virus of the equine herpesvirus 1 gene encoding glycoprotein gp13 and protection of immunized animals.

Authors:  P X Guo; S Goebel; S Davis; M E Perkus; B Languet; P Desmettre; G Allen; E Paoletti
Journal:  J Virol       Date:  1989-10       Impact factor: 5.103

4.  A murine model for studying EHV-1-induced abortion.

Authors:  A R Awan; J S Gibson; H J Field
Journal:  Res Vet Sci       Date:  1991-07       Impact factor: 2.534

5.  Expression of equine herpesvirus type 1 glycoprotein gp14 in Escherichia coli and in insect cells: a comparative study on protein processing and humoral immune responses.

Authors:  N Osterrieder; R Wagner; M Pfeffer; O R Kaaden
Journal:  J Gen Virol       Date:  1994-08       Impact factor: 3.891

6.  Cell-mediated antiviral response to equine herpesvirus type 1 demonstrated in a murine infection model by means of adoptive transfer of immune cells.

Authors:  M Azmi; H J Field
Journal:  J Gen Virol       Date:  1993-02       Impact factor: 3.891

7.  Expression of equine herpesvirus 1 glycoprotein D by using a recombinant baculovirus.

Authors:  D N Love; C W Bell; D Pye; S Edwards; M Hayden; G L Lawrence; D Boyle; T Pye; J M Whalley
Journal:  J Virol       Date:  1993-11       Impact factor: 5.103

8.  The DNA sequence of equine herpesvirus-1.

Authors:  E A Telford; M S Watson; K McBride; A J Davison
Journal:  Virology       Date:  1992-07       Impact factor: 3.616

9.  Baculovirus expressed herpes simplex virus type 1 glycoprotein C protects mice from lethal HSV-1 infection.

Authors:  H Ghiasi; R Kaiwar; A B Nesburn; S L Wechsler
Journal:  Antiviral Res       Date:  1992-06       Impact factor: 5.970

10.  Construction of a new family of high efficiency bacterial expression vectors: identification of cDNA clones coding for human liver proteins.

Authors:  K K Stanley; J P Luzio
Journal:  EMBO J       Date:  1984-06       Impact factor: 11.598
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  1 in total

1.  Deletion of the ORF2 gene of the neuropathogenic equine herpesvirus type 1 strain Ab4 reduces virulence while maintaining strong immunogenicity.

Authors:  Christiane L Schnabel; Christine L Wimer; Gillian Perkins; Susanna Babasyan; Heather Freer; Christina Watts; Alicia Rollins; Nikolaus Osterrieder; Bettina Wagner
Journal:  BMC Vet Res       Date:  2018-08-22       Impact factor: 2.741
  1 in total

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