Literature DB >> 1653556

The mechanism of action of the anti-herpes virus compound 2,3-dimethyl-6(2-dimethylaminoethyl)-6H-indolo-(2,3-b)quinoxaline.

J Harmenberg1, A Akesson-Johansson, A Gräslund, T Malmfors, J Bergman, B Wahren, S Akerfeldt, L Lundblad, S Cox.   

Abstract

The compound 2,3-dimethyl-6(2-dimethylaminoethyl)6H-indolo-(2,3-b)quinoxaline (B-220) has been shown to exhibit potent antiviral activity against herpes simplex virus type 1 (HSV-1), varicella-zoster virus (VZV) and cytomegalovirus (CMV). The mechanism of antiviral action of B-220 against HSV-1 has been studied; from the results it appears that B-220 binds by intercalation into the DNA helix and then disturbs steps that are vital for viral uncoating.

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Year:  1991        PMID： 1653556     DOI： 10.1016/0166-3542(91)90066-z

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  6 in total

1.  One-pot sequential coupling reactions as a new practical protocol for the synthesis of unsymmetrical 2,3-diethynyl quinoxalines and 4-ethynyl-substituted pyrrolo[1,2-a]quinoxalines.

Authors:  Ali Keivanloo; Saeed Lashkari; Mohammad Bakherad; Mahsa Fakharian; Sima Abbaspour
Journal:  Mol Divers       Date:  2020-04-16       Impact factor: 2.943

2.  N,N'-Bis[(E)-quinoxalin-2-ylmethyl-idene]-ethane-1,2-diamine.

Authors:  Digna Varghese; V Arun; Manju Sebastian; P Leeju; G Varsha; K K M Yusuff
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-01-31

3.  Crystal structure of 2-aza-niumyl-3-bromo-6-oxo-5,6-di-hydro-pyrido[1,2-a]quinoxalin-11-ium dibromide.

Authors:  Md Serajul Haque Faizi; Natalia O Sharkina; Turganbay S Iskenderov
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-01-01

4.  Quinoxaline Derivatives as Antiviral Agents: A Systematic Review.

Authors:  Marc Montana; Vincent Montero; Omar Khoumeri; Patrice Vanelle
Journal:  Molecules       Date:  2020-06-16       Impact factor: 4.411

5.  Convenient Synthesis of N-Alkyl-2-(3-phenyl-quinoxalin-2-ylsulfanyl)acetamides and Methyl-2-[2-(3-phenyl-quinoxalin-2-ylsulfanyl)acetylamino]alkanoates.

Authors:  Samir Mohamed El Rayes; Gaber El-Enany; Mohamed Sayed Gomaa; Ibrahim A I Ali; Walid Fathalla; Faheem Hyder Pottoo; Firdos Alam Khan
Journal:  ACS Omega       Date:  2022-09-15

6.  In vitro antimicrobial activities of animal-used quinoxaline 1,4-di-N-oxides against mycobacteria, mycoplasma and fungi.

Authors:  Yan Zhao; Guyue Cheng; Haihong Hao; Yuanhu Pan; Zhenli Liu; Menghong Dai; Zonghui Yuan
Journal:  BMC Vet Res       Date:  2016-09-06       Impact factor: 2.741
  6 in total

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