Literature DB >> 1652942

Retinoic acid and transforming growth factor beta differentially inhibit platelet-derived-growth-factor-induced Ito-cell activation.

B H Davis1, U R Rapp, N O Davidson.   

Abstract

Sinusoidal Ito cells (stellate or fat-storing cells) undergo excessive cellular proliferation before the establishment and progression of hepatic fibrosis and cirrhosis. Retinoic acid and transforming growth factor beta (TGF beta) both inhibit Ito-cell [3H]thymidine incorporation in serum-containing media. Serum-induced mitogenicity was dependent on platelet-derived growth factor (PDGF). Additionally, pre-treatment of Ito cells with retinoic acid and TGF beta blocked PDGF-induced cell proliferation. TGF beta, but not retinoic acid, diminished PDGF-receptor and smooth-muscle alpha-actin abundance.

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Year:  1991        PMID： 1652942      PMCID： PMC1151446          DOI： 10.1042/bj2780043

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  31 in total

1.  Modulation of collagen synthesis by fat-storing cells, isolated from CCl4- or vitamin A-treated rats.

Authors:  Y Shiratori; T Ichida; A Geerts; E Wisse
Journal:  Dig Dis Sci       Date:  1987-11       Impact factor: 3.199

2.  Immunodetection and quantitation of the two forms of transforming growth factor-beta (TGF-beta 1 and TGF-beta 2) secreted by cells in culture.

Authors:  D Danielpour; L L Dart; K C Flanders; A B Roberts; M B Sporn
Journal:  J Cell Physiol       Date:  1989-01       Impact factor: 6.384

3.  Correlation between Ito cells and fibrogenesis in an experimental model of hepatic fibrosis. A sequential stereological study.

Authors:  G Ballardini; S Degli Esposti; F B Bianchi; L B de Giorgi; A Faccani; L Biolchini; C A Busachi; E Pisi
Journal:  Liver       Date:  1983-02

4.  Double labelling of tissue combining tritiated thymidine autoradiography with immunodetection of bromodeoxyuridine: the autoradiographic significance of inhibition of thymidine incorporation into DNA by bromodeoxyuridine given simultaneously.

Authors:  W J Hume; J Thompson
Journal:  Cell Tissue Kinet       Date:  1989-09

5.  Retinol and extracellular collagen matrices modulate hepatic Ito cell collagen phenotype and cellular retinol binding protein levels.

Authors:  B H Davis; B M Pratt; J A Madri
Journal:  J Biol Chem       Date:  1987-07-25       Impact factor: 5.157

6.  Transforming growth factor alpha may be a physiological regulator of liver regeneration by means of an autocrine mechanism.

Authors:  J E Mead; N Fausto
Journal:  Proc Natl Acad Sci U S A       Date:  1989-03       Impact factor: 11.205

7.  Modulation of vitamin A metabolism during hepatic and intestinal cell culture.

Authors:  B H Davis; A Vucic
Journal:  Biochim Biophys Acta       Date:  1989-03-06

8.  The effect of retinol on Ito cell proliferation in vitro.

Authors:  B H Davis; A Vucic
Journal:  Hepatology       Date:  1988 Jul-Aug       Impact factor: 17.425

Review 9.  Some recent advances in the chemistry and biology of transforming growth factor-beta.

Authors:  M B Sporn; A B Roberts; L M Wakefield; B de Crombrugghe
Journal:  J Cell Biol       Date:  1987-09       Impact factor: 10.539

10.  Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms.

Authors:  G F Pierce; T A Mustoe; J Lingelbach; V R Masakowski; G L Griffin; R M Senior; T F Deuel
Journal:  J Cell Biol       Date:  1989-07       Impact factor: 10.539
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  9 in total

1.  Effects of retinoic acid on proliferation, phenotype and expression of cyclin-dependent kinase inhibitors in TGF-beta1-stimulated rat hepatic stellate cells.

Authors:  Guang-Cun Huang; Jin-Sheng Zhang; Yue-E Zhang
Journal:  World J Gastroenterol       Date:  2000-12       Impact factor: 5.742

2.  Effect of transforming growth factor beta and bone morphogenetic proteins on rat hepatic stellate cell proliferation and trans-differentiation.

Authors:  Hong Shen; Guo-Jiang Huang; Yue-Wen Gong
Journal:  World J Gastroenterol       Date:  2003-04       Impact factor: 5.742

3.  Growth arrest and decrease of alpha-SMA and type I collagen expression by palmitic acid in the rat hepatic stellate cell line PAV-1.

Authors:  Armand Abergel; Vincent Sapin; Nicolas Dif; Christophe Chassard; Claude Darcha; Julie Marcand-Sauvant; Brigitte Gaillard-Martinie; Edmond Rock; Pierre Dechelotte; Patrick Sauvant
Journal:  Dig Dis Sci       Date:  2006-04-27       Impact factor: 3.199

4.  Indomethacin and retinoic acid modify mouse intestinal inflammation and fibrosis: a role for SPARC.

Authors:  Borut Klopcic; Amber Appelbee; Warren Raye; Frances Lloyd; James C I Jooste; Cynthia Heather Forrest; Ian Craig Lawrance
Journal:  Dig Dis Sci       Date:  2008-06       Impact factor: 3.199

5.  Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture.

Authors:  L Wong; G Yamasaki; R J Johnson; S L Friedman
Journal:  J Clin Invest       Date:  1994-10       Impact factor: 14.808

6.  Effect of all-trans retinoic acid on liver fibrosis induced by common bile duct ligation in rats.

Authors:  Hui Wang; Zili Dan; Haiyan Jiang
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2008-10-10

7.  Prevention of cultured rat stellate cell transformation and endothelin-B receptor upregulation by retinoic acid.

Authors:  Xuedong Chi; Kristin Anselmi; Simon Watkins; Chandrashekhar R Gandhi
Journal:  Br J Pharmacol       Date:  2003-06       Impact factor: 8.739

8.  Retinoic acid suppresses the response to platelet-derived growth factor in human hepatic Ito-cell-like myofibroblasts: a post-receptor mechanism independent of raf/fos/jun/egr activation.

Authors:  B H Davis; D Coll; D W Beno
Journal:  Biochem J       Date:  1993-09-15       Impact factor: 3.857

Review 9.  Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets.

Authors:  A M Gressner; R Weiskirchen
Journal:  J Cell Mol Med       Date:  2006 Jan-Mar       Impact factor: 5.310
  9 in total

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