Literature DB >> 3665683

Modulation of collagen synthesis by fat-storing cells, isolated from CCl4- or vitamin A-treated rats.

Y Shiratori1, T Ichida, A Geerts, E Wisse.   

Abstract

In an attempt to elucidate the role of fat-storing cells (FSCs) in liver fibrosis, we investigated the collagen synthesis by FSCs freshly isolated from rats treated with CCl4, with vitamin A, and from untreated rats. FSCs from CCl4-treated rats contained a small number of lipid droplets and an abundant rough endoplasmic reticulum (RER), while those from vitamin A-treated rats showed numerous large lipid droplets and scanty RER. The population doubling times of FSCs isolated from normal, CCl4-treated, and vitamin A-treated rats were 38 +/- 4.3, 24 +/- 2.5, and 48 +/- 6.3 hr, respectively. The rate of collagen synthesis by FSCs from CCl4-treated rats was four- to sixfold enhanced, while collagen synthesis by FSCs from vitamin A-treated rats was suppressed. The ratio of collagen type I to type III produced by FSCs from CCl4 rats was enhanced as compared with control rats (94.7:5.3 vs 87.6:12.4). Therefore, FSCs can be considered to play an important role in the pathogenesis of liver fibrosis.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3665683     DOI： 10.1007/bf01296379

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  34 in total

1.  Use of a mixture of proteinase-free collagenases for the specific assay of radioactive collagen in the presence of other proteins.

Authors:  B Peterkofsky; R Diegelmann
Journal:  Biochemistry       Date:  1971-03-16       Impact factor: 3.162

2.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

3.  Biosynthesis of interstitial types of collagen by albumin-producing rat liver parenchymal cell (hepatocyte) clones in culture.

Authors:  R Hata; Y Ninomiya; Y Nagai; Y Tsukada
Journal:  Biochemistry       Date:  1980-01-08       Impact factor: 3.162

4.  Liver proline oxidase activity and collagen synthesis in rats with cirrhosis induced by carbon tetrachloride.

Authors:  M N Ehrinpreis; M A Giambrone; M Rojkind
Journal:  Biochim Biophys Acta       Date:  1980-04-17

5.  "Sternzellen" in the liver: perisinusoidal cells with special reference to storage of vitamin A.

Authors:  K Wake
Journal:  Am J Anat       Date:  1971-12

6.  Acetaldehyde and lactate stimulate collagen synthesis of cultured baboon liver myofibroblasts.

Authors:  E R Savolainen; M A Leo; R Timpl; C S Lieber
Journal:  Gastroenterology       Date:  1984-10       Impact factor: 22.682

7.  Collagen polymorphism in normal and cirrhotic human liver.

Authors:  J M Seyer; E T Hutcheson; A H Kang
Journal:  J Clin Invest       Date:  1977-02       Impact factor: 14.808

8.  Distribution of basement membrane proteins in normal and fibrotic human liver: collagen type IV, laminin, and fibronectin.

Authors:  E Hahn; G Wick; D Pencev; R Timpl
Journal:  Gut       Date:  1980-01       Impact factor: 23.059

9.  Contractile fibroblasts in chronic alcoholic cirrhosis.

Authors:  R Rudolph; W J McClure; M Woodward
Journal:  Gastroenterology       Date:  1979-04       Impact factor: 22.682

10.  The role of fat-storing cells in Disse space fibrogenesis in alcoholic liver disease.

Authors:  Y Minato; Y Hasumura; J Takeuchi
Journal:  Hepatology       Date:  1983 Jul-Aug       Impact factor: 17.425
View more
  12 in total

1.  Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors.

Authors:  S L Friedman; M J Arthur
Journal:  J Clin Invest       Date:  1989-12       Impact factor: 14.808

2.  Growth arrest and decrease of alpha-SMA and type I collagen expression by palmitic acid in the rat hepatic stellate cell line PAV-1.

Authors:  Armand Abergel; Vincent Sapin; Nicolas Dif; Christophe Chassard; Claude Darcha; Julie Marcand-Sauvant; Brigitte Gaillard-Martinie; Edmond Rock; Pierre Dechelotte; Patrick Sauvant
Journal:  Dig Dis Sci       Date:  2006-04-27       Impact factor: 3.199

3.  All-trans and 9-cis retinoic acid alter rat hepatic stellate cell phenotype differentially.

Authors:  K Hellemans; I Grinko; K Rombouts; D Schuppan; A Geerts
Journal:  Gut       Date:  1999-07       Impact factor: 23.059

4.  Retinoic acid modulates rat Ito cell proliferation, collagen, and transforming growth factor beta production.

Authors:  B H Davis; R T Kramer; N O Davidson
Journal:  J Clin Invest       Date:  1990-12       Impact factor: 14.808

5.  Contribution of hepatic parenchymal and nonparenchymal cells to hepatic fibrogenesis in biliary atresia.

Authors:  G A Ramm; V G Nair; K R Bridle; R W Shepherd; D H Crawford
Journal:  Am J Pathol       Date:  1998-08       Impact factor: 4.307

6.  Retinoic acid and transforming growth factor beta differentially inhibit platelet-derived-growth-factor-induced Ito-cell activation.

Authors:  B H Davis; U R Rapp; N O Davidson
Journal:  Biochem J       Date:  1991-08-15       Impact factor: 3.857

7.  Effects of vitamin A on collagen metabolism by cultured rat liver cells.

Authors:  S Takase; K Enyama; A Takada; M Tsutsumi
Journal:  Gastroenterol Jpn       Date:  1992-06

8.  Prevention of cultured rat stellate cell transformation and endothelin-B receptor upregulation by retinoic acid.

Authors:  Xuedong Chi; Kristin Anselmi; Simon Watkins; Chandrashekhar R Gandhi
Journal:  Br J Pharmacol       Date:  2003-06       Impact factor: 8.739

9.  Distinct populations of hepatic stellate cells in the mouse liver have different capacities for retinoid and lipid storage.

Authors:  Diana N D'Ambrosio; José L Walewski; Robin D Clugston; Paul D Berk; Richard A Rippe; William S Blaner
Journal:  PLoS One       Date:  2011-09-16       Impact factor: 3.240

10.  Bile acids induce hepatic differentiation of mesenchymal stem cells.

Authors:  Iris Sawitza; Claus Kordes; Silke Götze; Diran Herebian; Dieter Häussinger
Journal:  Sci Rep       Date:  2015-08-25       Impact factor: 4.379
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.