Literature DB >> 1652891

Genetic mapping of the beta 1 GABA receptor gene to human chromosome 4, using a tetranucleotide repeat polymorphism.

M Dean1, S Lucas-Derse, A Bolos, S J O'Brien, E F Kirkness, C M Fraser, D Goldman.   

Abstract

As more coding loci for functional human genes are described, there is a growing need to identify DNA polymorphisms in specific genes. By examining DNA sequences within the introns of the beta 1 subunit of the gamma-aminobutyric acid receptor gene, GABARB1, we found a tetranucleotide repeat sequence (GATA). Amplification of this region by using PCR revealed seven alleles and a high degree of polymorphism (PIC = .75) in human populations. DNAs from the CEPH families were typed for the GABARB1 intron polymorphism and were analyzed with respect to 20 linked markers on chromosome 4. The results permit placement of GABARB1 on the linkage map of chromosome 4, between D4S104 and ALB. These results affirm that sequence analysis of noncoding segments included within or adjacent to functional genes has value as a strategy to detect highly informative polymorphisms.

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Year:  1991        PMID： 1652891      PMCID： PMC1683131     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  21 in total

1.  Tetranucleotide repeat polymorphism in the apolipoprotein C-III gene.

Authors:  G Zuliani; H H Hobbs
Journal:  Nucleic Acids Res       Date:  1990-07-25       Impact factor: 16.971

2.  The murine GABAA receptor delta-subunit gene: structure and assignment to human chromosome 1.

Authors:  B Sommer; A Poustka; N K Spurr; P H Seeburg
Journal:  DNA Cell Biol       Date:  1990-10       Impact factor: 3.311

3.  Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family.

Authors:  P R Schofield; M G Darlison; N Fujita; D R Burt; F A Stephenson; H Rodriguez; L M Rhee; J Ramachandran; V Reale; T A Glencorse
Journal:  Nature       Date:  1987 Jul 16-22       Impact factor: 49.962

4.  Sequence and expression of human GABAA receptor alpha 1 and beta 1 subunits.

Authors:  P R Schofield; D B Pritchett; H Sontheimer; H Kettenmann; P H Seeburg
Journal:  FEBS Lett       Date:  1989-02-27       Impact factor: 4.124

5.  Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.

Authors:  J L Weber; P E May
Journal:  Am J Hum Genet       Date:  1989-03       Impact factor: 11.025

6.  A selective imidazobenzodiazepine antagonist of ethanol in the rat.

Authors:  P D Suzdak; J R Glowa; J N Crawley; R D Schwartz; P Skolnick; S M Paul
Journal:  Science       Date:  1986-12-05       Impact factor: 47.728

7.  Structural and functional basis for GABAA receptor heterogeneity.

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Journal:  Nature       Date:  1988-09-01       Impact factor: 49.962

8.  A hypervariable microsatellite revealed by in vitro amplification of a dinucleotide repeat within the cardiac muscle actin gene.

Authors:  M Litt; J A Luty
Journal:  Am J Hum Genet       Date:  1989-03       Impact factor: 11.025

9.  Localization of the Huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere.

Authors:  T C Gilliam; R E Tanzi; J L Haines; T I Bonner; A G Faryniarz; W J Hobbs; M E MacDonald; S V Cheng; S E Folstein; P M Conneally
Journal:  Cell       Date:  1987-08-14       Impact factor: 41.582

10.  Conserved arrangement of nested genes at the Drosophila Gart locus.

Authors:  S Henikoff; M K Eghtedarzadeh
Journal:  Genetics       Date:  1987-12       Impact factor: 4.562
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  7 in total

Review 1.  Human identity testing with PCR-based systems.

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Journal:  Mol Biotechnol       Date:  1999-12-01       Impact factor: 2.695

2.  A polymerase chain reaction-based microsatellite typing assay used for tumor cell line identification.

Authors:  B L King; A Lichtenstein; J Berenson; B M Kacinski
Journal:  Am J Pathol       Date:  1994-03       Impact factor: 4.307

3.  Variation in short tandem repeat sequences--a survey of twelve microsatellite loci for use as forensic identification markers.

Authors:  A Urquhart; C P Kimpton; T J Downes; P Gill
Journal:  Int J Legal Med       Date:  1994       Impact factor: 2.686

4.  Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials.

Authors:  J T Williams; H Begleiter; B Porjesz; H J Edenberg; T Foroud; T Reich; A Goate; P Van Eerdewegh; L Almasy; J Blangero
Journal:  Am J Hum Genet       Date:  1999-10       Impact factor: 11.025

5.  Benign adult familial myoclonus epilepsy (BAFME): an autosomal dominant form not linked to the dentatorubral pallidoluysian atrophy (DRPLA) gene.

Authors:  A Kuwano; F Takakubo; Y Morimoto; E Uyama; M Uchino; M Ando; T Yasuda; A Terao; T Hayama; R Kobayashi; I Kondo
Journal:  J Med Genet       Date:  1996-01       Impact factor: 6.318

6.  A gene for familial total anomalous pulmonary venous return maps to chromosome 4p13-q12.

Authors:  S Bleyl; L Nelson; S J Odelberg; H D Ruttenberg; B Otterud; M Leppert; K Ward
Journal:  Am J Hum Genet       Date:  1995-02       Impact factor: 11.025

7.  Microsatellite instability in ovarian neoplasms.

Authors:  B L King; M L Carcangiu; D Carter; M Kiechle; J Pfisterer; A Pfleiderer; B M Kacinski
Journal:  Br J Cancer       Date:  1995-08       Impact factor: 7.640
  7 in total

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