Literature DB >> 2465923

Sequence and expression of human GABAA receptor alpha 1 and beta 1 subunits.

P R Schofield1, D B Pritchett, H Sontheimer, H Kettenmann, P H Seeburg.   

Abstract

The deduced amino acid sequences of cDNA clones encoding human GABAA receptor alpha 1 and beta 1 subunits are presented. The human subunits display very high levels of sequence identity with the corresponding bovine receptor subunits. The cloned human GABAA receptor subunits induce the formation of GABA-gated chloride channels when expressed in mammalian cells.

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Year:  1989        PMID： 2465923     DOI： 10.1016/0014-5793(89)80563-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  23 in total

1.  Modeling the open and closed forms of GABAA receptor: analysis of ligand-receptor interactions for the GABA-binding site.

Authors:  V I Chupakhin; V A Palyulin; N S Zefirov
Journal:  Dokl Biochem Biophys       Date:  2006 May-Jun       Impact factor: 0.788

2.  Genetic mapping of the beta 1 GABA receptor gene to human chromosome 4, using a tetranucleotide repeat polymorphism.

Authors:  M Dean; S Lucas-Derse; A Bolos; S J O'Brien; E F Kirkness; C M Fraser; D Goldman
Journal:  Am J Hum Genet       Date:  1991-09       Impact factor: 11.025

Review 3.  GABAA-receptors: structural requirements and sites of gene expression in mammalian brain.

Authors:  H Mohler; P Malherbe; A Draguhn; J G Richards
Journal:  Neurochem Res       Date:  1990-02       Impact factor: 3.996

4.  Neuronally restricted RNA splicing regulates the expression of a novel GABAA receptor subunit conferring atypical functional properties [corrected; erratum to be published].

Authors:  P J Whiting; G McAllister; D Vassilatis; T P Bonnert; R P Heavens; D W Smith; L Hewson; R O'Donnell; M R Rigby; D J Sirinathsinghji; G Marshall; S A Thompson; K A Wafford; D Vasilatis
Journal:  J Neurosci       Date:  1997-07-01       Impact factor: 6.167

5.  Association between GABA(A) receptor subunit gene cluster and zolpidem-induced complex sleep behaviors in Han Chinese.

Authors:  Jui-Hsiu Tsai; Pinchen Yang; Hung-Hsun Lin; Kuang-Hung Cheng; Yi-Hsin Yang; Ming-Tsang Wu; Cheng-Chung Chen
Journal:  Sleep       Date:  2013-02-01       Impact factor: 5.849

6.  Infusion of Gabrα6 siRNA into the trigeminal ganglia increased the myogenic orofacial nociceptive response of ovariectomized rats treated with 17β-estradiol.

Authors:  P R Kramer; L L Bellinger
Journal:  Neuroscience       Date:  2014-08-12       Impact factor: 3.590

7.  Differences in the negative allosteric modulation of gamma-aminobutyric acid receptors elicited by 4'-chlorodiazepam and by a beta-carboline-3-carboxylate ester: a study with natural and reconstituted receptors.

Authors:  G Puia; M R Santi; S Vicini; D B Pritchett; P H Seeburg; E Costa
Journal:  Proc Natl Acad Sci U S A       Date:  1989-09       Impact factor: 11.205

8.  The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit.

Authors:  P B Wingrove; K A Wafford; C Bain; P J Whiting
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-10       Impact factor: 11.205

9.  Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina.

Authors:  G R Cutting; L Lu; B F O'Hara; L M Kasch; C Montrose-Rafizadeh; D M Donovan; S Shimada; S E Antonarakis; W B Guggino; G R Uhl
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-01       Impact factor: 11.205

10.  Molecular cloning and transformation of cyclodiene resistance in Drosophila: an invertebrate gamma-aminobutyric acid subtype A receptor locus.

Authors:  R H Ffrench-Constant; D P Mortlock; C D Shaffer; R J MacIntyre; R T Roush
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-15       Impact factor: 11.205
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