Literature DB >> 16527375

Synthesis and anti-bacterial activity of some novel 2-(6-fluorochroman-2-yl)-1-alkyl/acyl/aroyl-1H-benzimidazoles.

Bobba Venkata Siva Kumar1, Sanjay Dashrath Vaidya, Ramanatham Vinod Kumar, Shekar Bhaskar Bhirud, Ramchandra Bhimrao Mane.   

Abstract

Synthesis of some novel 2-(6-fluorochroman-2-yl)-1-alkyl/acyl/aroyl-1H-benzimidazoles by the condensation of o-phenylenediamine with 6-fluoro-3,4-dihydro-2H-chroman-2-carboxylic acid, and subsequent reactions with different types of electrophiles, have been reported. Some compounds exhibited promising anti-bacterial activity against Salmonella typhimurium; however, they showed poor activity against S. aureus. The biological activity against PDE IV for potential anti-asthamatic effect, and against DP-IV and PTP 1B for potential anti-diabetic effects was disappointing.

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Year:  2006        PMID： 16527375     DOI： 10.1016/j.ejmech.2006.01.006

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  10 in total

1.  Antibacterial and antiproliferative activity of novel 2-benzimidazolyl- and 2-benzothiazolyl-substituted benzo[b]thieno-2-carboxamides.

Authors:  Maja Cindrić; Mihaela Perić; Marijeta Kralj; Irena Martin-Kleiner; Marie-Hélène David-Cordonnier; Hana Čipčić Paljetak; Mario Matijašić; Donatella Verbanac; Grace Karminski-Zamola; Marijana Hranjec
Journal:  Mol Divers       Date:  2018-03-20       Impact factor: 2.943

2.  Novel benzimidazole derivatives; synthesis, bioactivity and molecular docking study as potent urease inhibitors.

Authors:  Ebrahim Saeedian Moghadam; Abdullah Mohammed Al-Sadi; Meysam Talebi; Massoud Amanlou; Mohsen Amini; Raid Abdel-Jalil
Journal:  Daru       Date:  2022-01-18       Impact factor: 4.088

3.  In-silico docking based design and synthesis of [1H,3H] imidazo[4,5-b] pyridines as lumazine synthase inhibitors for their effective antimicrobial activity.

Authors:  Sunil L Harer; Manish S Bhatia
Journal:  J Pharm Bioallied Sci       Date:  2014-10

4.  Synthesis, anti-microbial activity, cytotoxicity of some novel substituted (5-(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxybenzyl)benzofuran-2-yl)(phenyl)methanone analogs.

Authors:  Bhookya Shankar; Pochampally Jalapathi; Balabadra Saikrishna; Shaym Perugu; Vijjulatha Manga
Journal:  Chem Cent J       Date:  2018-01-09       Impact factor: 4.215

5.  Design, synthesis, biological evaluation and QSAR analysis of novel N-substituted benzimidazole derived carboxamides.

Authors:  Anja Beč; Marija Mioč; Branimir Bertoša; Marija Kos; Patricia Debogović; Marijeta Kralj; Kristina Starčević; Marijana Hranjec
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.756

6.  New Pyrazolo-Benzimidazole Mannich Bases with Antimicrobial and Antibiofilm Activities.

Authors:  Christina Zalaru; Florea Dumitrascu; Constantin Draghici; Isabela Tarcomnicu; Maria Marinescu; George Mihai Nitulescu; Rodica Tatia; Lucia Moldovan; Marcela Popa; Mariana Carmen Chifiriuc
Journal:  Antibiotics (Basel)       Date:  2022-08-12

7.  New (3-(1H-benzo[d]imidazol-2-yl))/(3-(3H-imidazo[4,5-b]pyridin-2-yl))-(1H-indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates as tubulin polymerization inhibitors.

Authors:  Kishore Mullagiri; V Lakshma Nayak; Satish Sunkari; Geeta Sai Mani; Sravanthi Devi Guggilapu; Burri Nagaraju; Abdullah Alarifi; Ahmed Kamal
Journal:  Medchemcomm       Date:  2017-12-12       Impact factor: 3.597

8.  Facile and efficient one-pot synthesis of benzimidazoles using lanthanum chloride.

Authors:  Yekkirala Venkateswarlu; Sudhagani Ramesh Kumar; Panuganti Leelavathi
Journal:  Org Med Chem Lett       Date:  2013-08-06

9.  Benzimidazole-1,2,3-triazole hybrid molecules: synthesis and evaluation for antibacterial/antifungal activity.

Authors:  Abdelaaziz Ouahrouch; Hana Ighachane; Moha Taourirte; Joachim W Engels; My Hassan Sedra; Hassan B Lazrek
Journal:  Arch Pharm (Weinheim)       Date:  2014-08-04       Impact factor: 3.751

Review 10.  Antimicrobial potential of 1H-benzo[d]imidazole scaffold: a review.

Authors:  Sumit Tahlan; Sanjiv Kumar; Balasubramanian Narasimhan
Journal:  BMC Chem       Date:  2019-02-04
  10 in total

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