OBJECTIVE: Recent studies have shown significant cognitive problems some months after critical illness. However there has been no research examining cognitive function within the intensive care unit (ICU) in non-delirious patients. DESIGN AND SETTING: A prospective study in an ICU. PATIENTS AND PARTICIPANTS: Using the Cambridge Neuropsychological Test Automated Battery (CANTAB), 30 long-stay, tracheal-intubated ICU patients were tested. Prior to testing on ICU the Confusion Assessment Measure (CAM-ICU) was administered and only those patients clearly not delirious and off sedation for several days were tested. The CANTAB tests were repeated a week after ICU discharge on the general ward and then again at 2 months. Sixteen patients completed the follow-up. RESULTS: While on ICU all 30 patients showed significant problems with strategic thinking and problem solving; 20 patients had some problems with memory. The degree of difficulty with problem solving on ICU was correlated with length of ICU stay (p=0.011), age (p=0.036) and length of hospital stay post ICU (p=0.044). Problems with memory in ICU and on the general ward were correlated with admission APACHE II score (p=0.004 and p=0.005 respectively). At the 2-month follow-up 5 of 16 patients (31%) scored below the 25 percentile for memory and 8 of 16 (50%) below the 25 percentile for problem solving (Slater TA, Jones C, Griffiths RD, Wilson S, Benjamin K (2004) Cognitive impairment during and after intensive care: a pilot study. Intensive Care Med 30 [Suppl 1]:S199). CONCLUSIONS: Difficulties with problem solving and poor memory remained a significant issue for 2 months after ICU discharge.
OBJECTIVE: Recent studies have shown significant cognitive problems some months after critical illness. However there has been no research examining cognitive function within the intensive care unit (ICU) in non-deliriouspatients. DESIGN AND SETTING: A prospective study in an ICU. PATIENTS AND PARTICIPANTS: Using the Cambridge Neuropsychological Test Automated Battery (CANTAB), 30 long-stay, tracheal-intubated ICU patients were tested. Prior to testing on ICU the Confusion Assessment Measure (CAM-ICU) was administered and only those patients clearly not delirious and off sedation for several days were tested. The CANTAB tests were repeated a week after ICU discharge on the general ward and then again at 2 months. Sixteen patients completed the follow-up. RESULTS: While on ICU all 30 patients showed significant problems with strategic thinking and problem solving; 20 patients had some problems with memory. The degree of difficulty with problem solving on ICU was correlated with length of ICU stay (p=0.011), age (p=0.036) and length of hospital stay post ICU (p=0.044). Problems with memory in ICU and on the general ward were correlated with admission APACHE II score (p=0.004 and p=0.005 respectively). At the 2-month follow-up 5 of 16 patients (31%) scored below the 25 percentile for memory and 8 of 16 (50%) below the 25 percentile for problem solving (Slater TA, Jones C, Griffiths RD, Wilson S, Benjamin K (2004) Cognitive impairment during and after intensive care: a pilot study. Intensive Care Med 30 [Suppl 1]:S199). CONCLUSIONS: Difficulties with problem solving and poor memory remained a significant issue for 2 months after ICU discharge.
Authors: E W Ely; R Margolin; J Francis; L May; B Truman; R Dittus; T Speroff; S Gautam; G R Bernard; S K Inouye Journal: Crit Care Med Date: 2001-07 Impact factor: 7.598
Authors: James C Jackson; Robert P Hart; Sharon M Gordon; Ayumi Shintani; Brenda Truman; Lisa May; E Wesley Ely Journal: Crit Care Med Date: 2003-04 Impact factor: 7.598
Authors: Christian Zauner; Alexandra Gendo; Ludwig Kramer; Georg C Funk; Edith Bauer; Peter Schenk; Klaus Ratheiser; Christian Madl Journal: Crit Care Med Date: 2002-05 Impact factor: 7.598
Authors: Tarek Sharshar; Francoise Gray; Geoffroy Lorin de la Grandmaison; Nicholas S Hopkinson; Ewen Ross; Anne Dorandeu; David Orlikowski; Jean-Claude Raphael; Philippe Gajdos; Djillali Annane Journal: Lancet Date: 2003-11-29 Impact factor: 79.321
Authors: E W Ely; S Gautam; R Margolin; J Francis; L May; T Speroff; B Truman; R Dittus; R Bernard; S K Inouye Journal: Intensive Care Med Date: 2001-11-08 Impact factor: 17.440
Authors: James C Jackson; Timothy D Girard; Sharon M Gordon; Jennifer L Thompson; Ayumi K Shintani; Jason W W Thomason; Brenda T Pun; Angelo E Canonico; Janet G Dunn; Gordon R Bernard; Robert S Dittus; E Wesley Ely Journal: Am J Respir Crit Care Med Date: 2010-03-18 Impact factor: 21.405
Authors: Joel Kohler; Friedrich Borchers; Matthias Endres; Björn Weiss; Claudia Spies; Julius Valentin Emmrich Journal: Dtsch Arztebl Int Date: 2019-09-20 Impact factor: 5.594
Authors: Timothy D Girard; James C Jackson; Pratik P Pandharipande; Brenda T Pun; Jennifer L Thompson; Ayumi K Shintani; Sharon M Gordon; Angelo E Canonico; Robert S Dittus; Gordon R Bernard; E Wesley Ely Journal: Crit Care Med Date: 2010-07 Impact factor: 7.598
Authors: R Scott Watson; Sheri S Crow; Mary E Hartman; Jacques Lacroix; Folafoluwa O Odetola Journal: Pediatr Crit Care Med Date: 2017-03 Impact factor: 3.624
Authors: Annemiek E Wolters; Arjen J C Slooter; Arendina W van der Kooi; Diederik van Dijk Journal: Intensive Care Med Date: 2013-01-18 Impact factor: 17.440
Authors: James C Jackson; Alessandro Morandi; Timothy D Girard; Kristen Merkle; Amy J Graves; Jennifer L Thompson; Ayumi K Shintani; Max L Gunther; Christopher J Cannistraci; Baxter P Rogers; John C Gore; Hillary J Warrington; E Wesley Ely; Ramona O Hopkins Journal: J Crit Care Date: 2015-01-30 Impact factor: 3.425
Authors: Maria C Duggan; Li Wang; Jo Ellen Wilson; Robert S Dittus; E Wesley Ely; James C Jackson Journal: J Crit Care Date: 2016-08-31 Impact factor: 3.425