James C Jackson1, Alessandro Morandi2, Timothy D Girard3, Kristen Merkle4, Amy J Graves5, Jennifer L Thompson6, Ayumi K Shintani7, Max L Gunther8, Christopher J Cannistraci9, Baxter P Rogers10, John C Gore11, Hillary J Warrington12, E Wesley Ely3, Ramona O Hopkins13. 1. Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN; Research Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN. Electronic address: james.c.jackson@vanderbilt.edu. 2. Department of Rehabilitation and Aged Care Unit, Hospital Ancelle, Cremona, Italy. 3. Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; Geriatric Research, Education and Clinical Center (GRECC) Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN. 4. Vanderbilt University Institute of Imaging Sciences, Nashville, TN. 5. Department of Urologic Surgery, Vanderbilt University School of Medicine, Nashville, TN. 6. Department of Clinical Epidemiology and Biostatistics, Osaka University, Osaka, Japan. 7. Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN. 8. Vanderbilt University Institute of Imaging Sciences, Nashville, TN; Department of Psychology, Vanderbilt University, Nashville, TN; Department of Psychology, Southern Methodist University, Dallas, TX. 9. Department of Biomedical Engineering, Vanderbilt University School of Engineering, Nashville, TN. 10. Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN; Department of Biomedical Engineering, Vanderbilt University School of Engineering, Nashville, TN; Department of Radiology and Radiological Sciences, Vanderbilt University School of Medicine, Nashville, TN. 11. Department of Biomedical Engineering, Vanderbilt University School of Engineering, Nashville, TN; Department of Radiology and Radiological Sciences, Vanderbilt University School of Medicine, Nashville, TN. 12. Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN. 13. Department of Psychology, Brigham Young University, Provo, UT; Department of Medicine, Pulmonary and Critical Care Division, Intermountain Medical Center, Murray UT; Neuroscience Center, Brigham Young University, Provo, UT.
Abstract
PURPOSE: We undertook this pilot prospective cohort investigation to examine the feasibility of functional magnetic resonance imaging (fMRI) assessments in survivors of critical illness and to analyze potential associations between delirium and brain activation patterns observed during a working memory task (N-back) at hospital discharge and 3-month follow-up. MATERIALS AND METHODS: At hospital discharge and 3 months later, fMRI assessed subjects' functional activity during an N-back task. Multiple linear regression was used to examine associations between duration of delirium and brain activity, and elastic net regression was used to assess the relationship between brain activation patterns at 3 months and cognitive outcomes at 12 months. RESULTS: Of 47 patients who underwent fMRI at discharge, 38 (80%) completed the protocol; of 37 who underwent fMRI at 3 months, 34 (91%) completed the protocol. At discharge, the mean (SD) percentage of correct responses on the most challenging version (the N2 version) of the N-back task was 70.4 (23.2; range of 20-100) compared with 76 (23.4; range of 33-100) at 3 months. No association was observed between delirium duration in the hospital and brain region activity in any brain region at discharge or 3 months after adjusting for relevant covariates (P values across all 11 brain regions of interest were >.25). CONCLUSIONS: Our data support the feasibility of using fMRI in survivors of critical illness at 3-month follow-up but not at discharge. In this small study, delirium was not associated with distinct or abnormal brain activation patterns, although overall performance on a cognitive task of working memory was poorer than observed in other cohorts of individuals with medically related executive dysfunction, mild cognitive impairment, and mild traumatic brain injury.
PURPOSE: We undertook this pilot prospective cohort investigation to examine the feasibility of functional magnetic resonance imaging (fMRI) assessments in survivors of critical illness and to analyze potential associations between delirium and brain activation patterns observed during a working memory task (N-back) at hospital discharge and 3-month follow-up. MATERIALS AND METHODS: At hospital discharge and 3 months later, fMRI assessed subjects' functional activity during an N-back task. Multiple linear regression was used to examine associations between duration of delirium and brain activity, and elastic net regression was used to assess the relationship between brain activation patterns at 3 months and cognitive outcomes at 12 months. RESULTS: Of 47 patients who underwent fMRI at discharge, 38 (80%) completed the protocol; of 37 who underwent fMRI at 3 months, 34 (91%) completed the protocol. At discharge, the mean (SD) percentage of correct responses on the most challenging version (the N2 version) of the N-back task was 70.4 (23.2; range of 20-100) compared with 76 (23.4; range of 33-100) at 3 months. No association was observed between delirium duration in the hospital and brain region activity in any brain region at discharge or 3 months after adjusting for relevant covariates (P values across all 11 brain regions of interest were >.25). CONCLUSIONS: Our data support the feasibility of using fMRI in survivors of critical illness at 3-month follow-up but not at discharge. In this small study, delirium was not associated with distinct or abnormal brain activation patterns, although overall performance on a cognitive task of working memory was poorer than observed in other cohorts of individuals with medically related executive dysfunction, mild cognitive impairment, and mild traumatic brain injury.
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