PURPOSE: To determine whether the upper cervical cord area (UCCA) is influenced by disease effect in early relapsing-remitting multiple sclerosis (MS), using statistical modeling to account for potential covariates. MATERIALS AND METHODS: A cohort of 39 patients were studied cross-sectionally within three years of first symptom onset (median disease duration = 1.6 years) and compared with 26 healthy controls. The UCCA was measured from axial reconstructions of three-dimensional T1-weighted scans with automated detection of the edge of the cord. Statistical analysis adjusted for factors such as total intracranial volume (TICV) and gender. Clinical correlations, in particular those thought likely to be related to cord pathology, were also investigated. RESULTS: No significant disease effect was noted on UCCA (P = 0.685), although there was borderline evidence of a lower UCCA in patients with symptoms of bowel or bladder disturbance (P = 0.043). A strong association was noted between UCCA and TICV (r = 0.558; P < or = 0.001), and there was a trend for females to have a smaller UCCA (P = 0.062). The latter finding appeared to reflect a gender-related difference in TICV (P < or = 0.001). CONCLUSION: Atrophy of the upper cervical cord is not readily apparent in most patients early in the course of relapsing-remitting MS. In evaluations of disease-related changes in the UCCA in cross-sectional studies, TICV and gender should be considered as potentially confounding covariates. 2006 Wiley-Liss, Inc.
PURPOSE: To determine whether the upper cervical cord area (UCCA) is influenced by disease effect in early relapsing-remitting multiple sclerosis (MS), using statistical modeling to account for potential covariates. MATERIALS AND METHODS: A cohort of 39 patients were studied cross-sectionally within three years of first symptom onset (median disease duration = 1.6 years) and compared with 26 healthy controls. The UCCA was measured from axial reconstructions of three-dimensional T1-weighted scans with automated detection of the edge of the cord. Statistical analysis adjusted for factors such as total intracranial volume (TICV) and gender. Clinical correlations, in particular those thought likely to be related to cord pathology, were also investigated. RESULTS: No significant disease effect was noted on UCCA (P = 0.685), although there was borderline evidence of a lower UCCA in patients with symptoms of bowel or bladder disturbance (P = 0.043). A strong association was noted between UCCA and TICV (r = 0.558; P < or = 0.001), and there was a trend for females to have a smaller UCCA (P = 0.062). The latter finding appeared to reflect a gender-related difference in TICV (P < or = 0.001). CONCLUSION: Atrophy of the upper cervical cord is not readily apparent in most patients early in the course of relapsing-remitting MS. In evaluations of disease-related changes in the UCCA in cross-sectional studies, TICV and gender should be considered as potentially confounding covariates. 2006 Wiley-Liss, Inc.
Authors: Christina Engl; Paul Schmidt; Milan Arsic; Christine C Boucard; Viola Biberacher; Michael Röttinger; Thorleif Etgen; Sabine Nunnemann; Nikolaos Koutsouleris; Maximilian Reiser; Eva M Meisenzahl; Mark Mühlau Journal: Neuroradiology Date: 2013-05-29 Impact factor: 2.804
Authors: Nico Papinutto; Carlo Asteggiano; Antje Bischof; Tristan J Gundel; Eduardo Caverzasi; William A Stern; Stefano Bastianello; Stephen L Hauser; Roland G Henry Journal: J Neuroimaging Date: 2019-09-30 Impact factor: 2.486
Authors: Nico Papinutto; Christian Cordano; Carlo Asteggiano; Eduardo Caverzasi; Maria Luisa Mandelli; Michael Lauricella; Nicole Yabut; Matthew Neylan; Gina Kirkish; Maria Luisa Gorno-Tempini; Roland G Henry Journal: J Neuroimaging Date: 2020-07-08 Impact factor: 2.486
Authors: Nico Papinutto; Regina Schlaeger; Valentina Panara; Eduardo Caverzasi; Sinyeob Ahn; Kevin J Johnson; Alyssa H Zhu; William A Stern; Gerhard Laub; Stephen L Hauser; Roland G Henry Journal: J Magn Reson Imaging Date: 2014-12-08 Impact factor: 4.813
Authors: M P Sampat; A M Berger; B C Healy; P Hildenbrand; J Vass; D S Meier; T Chitnis; H L Weiner; R Bakshi; C R G Guttmann Journal: AJNR Am J Neuroradiol Date: 2009-08-20 Impact factor: 3.825
Authors: Mark A Horsfield; Stefania Sala; Mohit Neema; Martina Absinta; Anshika Bakshi; Maria Pia Sormani; Maria A Rocca; Rohit Bakshi; Massimo Filippi Journal: Neuroimage Date: 2010-01-07 Impact factor: 6.556
Authors: Jiwon Oh; Michaela Seigo; Shiv Saidha; Elias Sotirchos; Kathy Zackowski; Min Chen; Jerry Prince; Marie Diener-West; Peter A Calabresi; Daniel S Reich Journal: J Neuroimaging Date: 2014-03-05 Impact factor: 2.486
Authors: Z Liptak; A M Berger; M P Sampat; A Charil; O Felsovalyi; B C Healy; P Hildenbrand; S J Khoury; H L Weiner; R Bakshi; C R G Guttmann Journal: AJNR Am J Neuroradiol Date: 2008-06-12 Impact factor: 3.825