| Literature DB >> 16516351 |
Hélio A Stefani1, Carlindo B Oliveira, Roberta B Almeida, Claudio M P Pereira, Rodolpho C Braga, Rodrigo Cella, Vanessa C Borges, Lucielli Savegnago, Cristina W Nogueira.
Abstract
An efficient and simple synthetic protocol for the Biginelli reaction has been developed for the preparation of several new dihydropyrimidinones, under ultrasound irradiation in the presence of NH(4)Cl, in good yields and short reaction time. Some of the synthesized compounds were tested in vitro for their antioxidant activity. All of the selected compounds showed some antioxidant activity. Analogues compounds 3b and 4b exhibited a strong activity against lipid peroxidation induced by Fe + EDTA, while compounds 3b and 3d were the most potent in reducing ROS levels.Entities:
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Year: 2006 PMID： 16516351 DOI： 10.1016/j.ejmech.2006.01.007
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514