| Literature DB >> 16513347 |
Douglas D Young1, Alexander Deiters.
Abstract
We report the light-activation of allosteric cis and trans acting ribozymes via decaging of a small organic molecule ligand. To achieve this effectively, we introduce an optimized N-caging group based on a nitrobenzyl core structure. This approach can potentially be employed toward a light-induced control of gene function.Entities:
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Year: 2006 PMID： 16513347 DOI： 10.1016/j.bmcl.2006.02.034
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823