| Literature DB >> 16499312 |
Roger G Linington1, Marilyn Robertson, Annick Gauthier, B Brett Finlay, John B MacMillan, Tadeusz F Molinski, Rob van Soest, Raymond J Andersen.
Abstract
A screening program aimed at discovering inhibitors of the bacterial type III secretion system identified the MeOH extract of the Caribbean sponge Caminus sphaeroconia as an active hit in the initial assay. Bioassay-guided fractionation of the crude extract led to the isolation of caminosides A (1) to D (4), a family of antimicrobial glycolipids. The structures of the three new caminosides B (2) to D (4) have been elucidated by spectroscopic analysis.Entities:
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Year: 2006 PMID： 16499312 DOI： 10.1021/np050192h
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050