Literature DB >> 16491318

Defatted milled grape seed protects adriamycin-treated hepatocytes against oxidative damage.

Victoria Valls-Belles1, Mari Carmen Torres, Pilar Muñiz, Sagrario Beltran, Jesús Roman Martinez-Alvarez, Pilar Codoñer-Franch.   

Abstract

Defatted milled grape seed (DMGS) is a wine by-product obtained from the oil extraction of the grape seed that contains different types of phenolic compounds. The present study was designed to evaluate the possible protective effect of DMGS on toxicity induced by adriamycin (ADR) in isolated rat hepatocytes. The study was carried out by examining the results of lactate dehydrogenase (LDH) release to estimate cytotoxicity; the thiobarbituric acid reactant substances (TBARS) and carbonyl group levels were measured as biomarkers of oxidative stress and ATP and GSH levels as estimation of intracellular effect. The results showed that DMGS extract protects the cellular membrane from oxidative damage and consequently prevents protein and lipid oxidation. The levels of ATP and GSH changes for the ADR toxicity were restored to control value in the presence of DMGS extract. The experimental results suggest that this wine by-product may be used to decrease oxidative stress.

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Year:  2006        PMID： 16491318     DOI： 10.1007/s00394-006-0591-1

Source DB:  PubMed          Journal:  Eur J Nutr        ISSN： 1436-6207            Impact factor:   5.614


  43 in total

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Journal:  Mol Aspects Med       Date:  2002 Feb-Jun

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4.  A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples.

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Journal:  Anal Biochem       Date:  1978-06-15       Impact factor: 3.365

Review 5.  Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract.

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Journal:  Mutat Res       Date:  2003 Feb-Mar       Impact factor: 2.433

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8.  Effect of inclusion of defatted grape seed meal in the diet on digestion and performance of growing rabbits.

Authors:  J García; N Nicodemus; R Carabaño; J C De Blass
Journal:  J Anim Sci       Date:  2002-01       Impact factor: 3.159

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Authors:  V Lee; A K Randhawa; P K Singal
Journal:  Am J Physiol       Date:  1991-10

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Review 3.  Biological activities of polyphenols from grapes.

Authors:  En-Qin Xia; Gui-Fang Deng; Ya-Jun Guo; Hua-Bin Li
Journal:  Int J Mol Sci       Date:  2010-02-04       Impact factor: 5.923

4.  Effect of beer consumption on levels of complex I and complex IV liver and heart mitochondrial enzymes and coenzymes Q9 and Q10 in adriamycin-treated rats.

Authors:  Victoria Valls-Belles; Carmen Torres; Pilar Muñiz; Pilar Codoñer-Franch
Journal:  Eur J Nutr       Date:  2009-10-20       Impact factor: 5.614

Review 5.  Grape Seed Oil Compounds: Biological and Chemical Actions for Health.

Authors:  Juliano Garavaglia; Melissa M Markoski; Aline Oliveira; Aline Marcadenti
Journal:  Nutr Metab Insights       Date:  2016-08-16

Review 6.  Berry Phenolic Antioxidants - Implications for Human Health?

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  6 in total

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