| Literature DB >> 16480978 |
Matthew V Covey1, Michael P Murphy, Catherine E Hobbs, Robin A J Smith, Dorothy E Oorschot.
Abstract
A mitochondria-targeted antioxidant, Mito Vitamin E (MitoVit E), has previously been shown to prevent mitochondrial oxidative damage. The aim of this study was to investigate the effect of MitoVit E on neuronal survival in the rat striatum after acute perinatal hypoxia-ischemia. Continuous striatal infusion with 4.35 microM, 43.5 microM, or 148 microM of MitoVit E before, during, and after hypoxia-ischemia was not neuroprotective for striatal medium-spiny neurons. Pre- or posttreatment with 435 microM MitoVit E was neurotoxic. These results suggest that MitoVit E is not significantly neuroprotective for striatal medium-spiny neurons after acute perinatal hypoxic-ischemic brain injury. The results also suggest that mitochondrial oxidative damage does not contribute significantly to the death of striatal medium-spiny neurons after perinatal hypoxia-ischemia.Entities:
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Year: 2006 PMID： 16480978 DOI： 10.1016/j.expneurol.2005.12.026
Source DB: PubMed Journal: Exp Neurol ISSN： 0014-4886 Impact factor: 5.330