Literature DB >> 24060637

Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes.

Huajun Jin1, Arthi Kanthasamy1, Anamitra Ghosh1, Vellareddy Anantharam1, Balaraman Kalyanaraman2, Anumantha G Kanthasamy3.   

Abstract

Parkinson's disease is a progressive neurodegenerative disease in the elderly, and no cure or disease-modifying therapies exist. Several lines of evidence suggest that mitochondrial dysfunction and oxidative stress have a central role in the dopaminergic neurodegeneration of Parkinson's disease. In this context, mitochondria-targeted therapies that improve mitochondrial function may have great promise in the prevention and treatment of Parkinson's disease. In this review, we discuss the recent developments in mitochondria-targeted antioxidants and their potential beneficial effects as a therapy for ameliorating mitochondrial dysfunction in Parkinson's disease.
© 2013.

Entities:  

Keywords:  Mitochondria-targeted antioxidant; Mitochondrial dysfunction; Neuroprotection; Oxidative stress; Parkinson's disease

Mesh：

Substances：

Year:  2013        PMID： 24060637      PMCID： PMC3961561          DOI： 10.1016/j.bbadis.2013.09.007

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  191 in total

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6.  Preferential Heme Oxygenase-1 Activation in Striatal Astrocytes Antagonizes Dopaminergic Neuron Degeneration in MPTP-Intoxicated Mice.

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8.  Time to get Personal: A Framework for Personalized Targeting of Oxidative Stress in Neurotoxicity and Neurodegenerative Disease.

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