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Literature DB >> 17519949

Mitochondrial medicine: pharmacological targeting of mitochondria in disease.

Abstract

Mitochondria play a central role in cell life and death and are known to be important in a wide range of diseases including the cancer, diabetes, cardiovascular disease, and the age-related neurodegenerative diseases. The unique structural and functional characteristics of mitochondria enable the selective targeting of drugs designed to modulate the function of this organelle for therapeutic gain. This review discusses mitochondrial drug targeting strategies and a variety of novel mitochondrial drug targets including the electron transport chain, mitochondrial permeability transition, Bcl-2 family proteins and mitochondrial DNA. Mitochondrial drug-targeting strategies will open up avenues for manipulating mitochondrial functions and allow for selective protection or eradication of cells for therapeutic gain in a variety of diseases.

Entities: Disease Gene

Mesh：

Substances：

Year: 2007 PMID： 17519949 PMCID： PMC2189819 DOI： 10.1038/sj.bjp.0707288

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

127 in total

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Journal: J Liposome Res Date: 2006 Impact factor: 3.648

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5. Superoxide activates mitochondrial uncoupling proteins.

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Journal: Nature Date: 2002-01-03 Impact factor: 49.962

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7. MKT-077, a novel rhodacyanine dye in clinical trials, exhibits anticarcinoma activity in preclinical studies based on selective mitochondrial accumulation.

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Journal: Cancer Res Date: 1996-02-01 Impact factor: 12.701

8. Multiple Q-cycle bypass reactions at the Qo site of the cytochrome bc1 complex.

Authors: Florian Muller; Antony R Crofts; David M Kramer
Journal: Biochemistry Date: 2002-06-25 Impact factor: 3.162

9. Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes.

Authors: D B Zorov; C R Filburn; L O Klotz; J L Zweier; S J Sollott
Journal: J Exp Med Date: 2000-10-02 Impact factor: 14.307

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Authors: Matthias L Jauslin; Thomas Meier; Robin A J Smith; Michael P Murphy
Journal: FASEB J Date: 2003-08-15 Impact factor: 5.191

59 in total

1. Carnosic Acid Suppresses the H₂O₂-Induced Mitochondria-Related Bioenergetics Disturbances and Redox Impairment in SH-SY5Y Cells: Role for Nrf2.

Authors: Marcos Roberto de Oliveira; Gustavo da Costa Ferreira; Alessandra Peres; Simone Morelo Dal Bosco
Journal: Mol Neurobiol Date: 2017-01-13 Impact factor: 5.590

2. Danthron triggers ROS and mitochondria-mediated apoptotic death in C6 rat glioma cells through caspase cascades, apoptosis-inducing factor and endonuclease G multiple signaling.

Authors: Shang-Ming Chiou; Chiz-Hao Chiu; Su-Tso Yang; Jai-Sing Yang; Hui-Ying Huang; Chao-Lin Kuo; Po-Yuan Chen; Jing-Gung Chung
Journal: Neurochem Res Date: 2012-05-17 Impact factor: 3.996

Review 3. Mitochondria as a target in treatment.

Authors: Marie-Céline Frantz; Peter Wipf
Journal: Environ Mol Mutagen Date: 2010-06 Impact factor: 3.216

4. Protective effects of asiatic acid on rotenone- or H2O2-induced injury in SH-SY5Y cells.

Authors: Yuyun Xiong; Hongqun Ding; Minfang Xu; Jing Gao
Journal: Neurochem Res Date: 2008-09-19 Impact factor: 3.996

5. Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells.

Authors: Min-fang Xu; Yu-yun Xiong; Jian-kang Liu; Jin-jun Qian; Li Zhu; Jing Gao
Journal: Acta Pharmacol Sin Date: 2012-03-26 Impact factor: 6.150

10. High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects.

Authors: Sunil Sahdeo; Alexey Tomilov; Kelly Komachi; Christine Iwahashi; Sandipan Datta; Owen Hughes; Paul Hagerman; Gino Cortopassi
Journal: Mitochondrion Date: 2014-07-14 Impact factor: 4.160