Literature DB >> 16457589

Precise characterization of human histones in the H2A gene family by top down mass spectrometry.

Michael T Boyne1, James J Pesavento, Craig A Mizzen, Neil L Kelleher.   

Abstract

Top Down analysis revealed that at least fourteen genes encoding histone H2A are coexpressed in HeLa cells. Characterization of these species revealed that all except H2A.Z and H2A.F/Z were alpha-N-acetylated, H2A.O and H2A.C,D,I,N,P were the most abundant, and those exceeding approximately 10% abundance lacked post-translational modifications. This unequivocal identification of H2A forms illustrates the advantages of Top Down Mass Spectrometry and provides a global perspective of H2A regulation through the cell cycle.

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Year:  2006        PMID： 16457589     DOI： 10.1021/pr050269n

Source DB:  PubMed          Journal:  J Proteome Res        ISSN： 1535-3893            Impact factor:   4.466


  70 in total

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5.  Online matrix removal platform for coupling gel-based separations to whole protein electrospray ionization mass spectrometry.

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Journal:  J Proteome Res       Date:  2015-04-15       Impact factor: 4.466

6.  Liquid chromatography mass spectrometry profiling of histones.

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Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2007-01-07       Impact factor: 3.205

7.  Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle.

Authors:  James J Pesavento; Hongbo Yang; Neil L Kelleher; Craig A Mizzen
Journal:  Mol Cell Biol       Date:  2007-10-29       Impact factor: 4.272

Review 8.  Decoding protein modifications using top-down mass spectrometry.

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Review 9.  Accurate mass measurements in proteomics.

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Review 10.  Mass spectrometry-based strategies for characterization of histones and their post-translational modifications.

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Journal:  Expert Rev Proteomics       Date:  2007-04       Impact factor: 3.940
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