Literature DB >> 16450306

New cytotoxic guttiferone analogues from Garcinia virgata from New Caledonia.

Joumaa Merza1, Sabine Mallet, Marc Litaudon, Vincent Dumontet, Denis Séraphin, Pascal Richomme.   

Abstract

There are thirteen endemic species belonging to the genus Garcinia in New Caledonia. Among them, G. virgata is an evergreen tree mainly growing in the rain forests of this island. Fractionation of the cyclohexane extract of the stem bark of this plant produced the known benzophenones guttiferone E and xanthochymol, together with two new guttiferone analogues, namely guttiferones I and J. The structures of these benzophenones were mainly elucidated using 1D and 2D NMR spectroscopy. Compounds and were weakly cytotoxic on the KB cell line with IC50 values of 4.70 and 5.0 microg/mL respectively.

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Year:  2006        PMID: 16450306     DOI: 10.1055/s-2005-873185

Source DB:  PubMed          Journal:  Planta Med        ISSN: 0032-0943            Impact factor:   3.352


  7 in total

1.  Guttiferones K and L, antiproliferative compounds of Rheedia calcicola from the Madagascar rain forest.

Authors:  Shugeng Cao; Peggy J Brodie; James S Miller; Fidy Ratovoson; Chris Birkinshaw; Sennen Randrianasolo; Etienne Rakotobe; Vincent E Rasamison; David G I Kingston
Journal:  J Nat Prod       Date:  2007-03-10       Impact factor: 4.050

Review 2.  Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets.

Authors:  Armelle T Mbaveng; Victor Kuete; Thomas Efferth
Journal:  Front Pharmacol       Date:  2017-06-02       Impact factor: 5.810

3.  An efficient oxidative dearomatization-radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products.

Authors:  Nicholas A McGrath; Joshua R Binner; Georgios Markopoulos; Matthew Brichacek; Jon T Njardarson
Journal:  Chem Commun (Camb)       Date:  2010-07-07       Impact factor: 6.222

4.  Gastroprotective effects of extracts and guttiferone A isolated from Garcinia achachairu Rusby (Clusiaceae) against experimentally induced gastric lesions in mice.

Authors:  Rivaldo Niero; Marlova Manhabosco Dal Molin; Suellen Silva; Natália Santos Damian; Láis Orlof Maia; Franco Delle Monache; Valdir Cechinel Filho; Sérgio Faloni de Andrade
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2012-08-29       Impact factor: 3.000

5.  Benzophenones and biflavonoids from Rheedia edulis.

Authors:  Ulyana Muñoz Acuña; Mario Figueroa; Adam Kavalier; Nikola Jancovski; Margaret J Basile; Edward J Kennelly
Journal:  J Nat Prod       Date:  2010-10-28       Impact factor: 4.050

6.  Prenylated Polyphenols from Clusiaceae and Calophyllaceae with Immunomodulatory Activity on Endothelial Cells.

Authors:  Caroline Rouger; Sylvain Pagie; Séverine Derbré; Anne-Marie Le Ray; Pascal Richomme; Béatrice Charreau
Journal:  PLoS One       Date:  2016-12-01       Impact factor: 3.240

7.  Targeting MHC Regulation Using Polycyclic Polyprenylated Acylphloroglucinols Isolated from Garcinia bancana.

Authors:  Chloé Coste; Nathalie Gérard; Chau Phi Dinh; Antoine Bruguière; Caroline Rouger; Sow Tein Leong; Khalijah Awang; Pascal Richomme; Séverine Derbré; Béatrice Charreau
Journal:  Biomolecules       Date:  2020-09-02
  7 in total

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