Literature DB >> 20607196

An efficient oxidative dearomatization-radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products.

Nicholas A McGrath1, Joshua R Binner, Georgios Markopoulos, Matthew Brichacek, Jon T Njardarson.   

Abstract

Detailed in this communication is an efficient synthetic approach towards the guttiferone family of natural products. Oxidatively unraveling a para-quinone monoketal followed by consecutive 5-exo radical cyclizations provides the bicyclic core. An additional strength of this approach is a late stage asymmetric desymmetrization of an advanced symmetric intermediate.

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Year:  2010        PMID： 20607196      PMCID： PMC3107033          DOI： 10.1039/c0cc01419b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  30 in total

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  7 in total

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