Literature DB >> 18332171

Mouse beta-defensin-14, an antimicrobial ortholog of human beta-defensin-3.

Kerstin Hinrichsen1, Rainer Podschun, Sabine Schubert, Jens M Schröder, Jürgen Harder, Ehrhardt Proksch.   

Abstract

Searching the database for mouse homologs of the antimicrobial peptide human beta-defensin-3 (hBD-3) revealed highest identity (69%) to mouse beta-defensin-14 (mBD-14). Recombinant mBD-14 exhibited broad-spectrum, nanomolar microbicidal activity. Treatment of keratinocytes with gamma interferon or transforming growth factor alpha increased mBD-14 gene expression. These data suggest that mBD-14 is the functional ortholog of hBD-3.

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Year:  2008        PMID： 18332171      PMCID： PMC2346663          DOI： 10.1128/AAC.01308-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  Antimicrobial peptides of multicellular organisms.

Authors:  Michael Zasloff
Journal:  Nature       Date:  2002-01-24       Impact factor: 49.962

2.  Improved prediction of signal peptides: SignalP 3.0.

Authors:  Jannick Dyrløv Bendtsen; Henrik Nielsen; Gunnar von Heijne; Søren Brunak
Journal:  J Mol Biol       Date:  2004-07-16       Impact factor: 5.469

3.  Differential regulation of beta-defensin expression in human skin by microbial stimuli.

Authors:  Ole E Sørensen; Dharma R Thapa; Adam Rosenthal; Lide Liu; Alice A Roberts; Tomas Ganz
Journal:  J Immunol       Date:  2005-04-15       Impact factor: 5.422

4.  Innate antimicrobial peptide protects the skin from invasive bacterial infection.

Authors:  V Nizet; T Ohtake; X Lauth; J Trowbridge; J Rudisill; R A Dorschner; V Pestonjamasp; J Piraino; K Huttner; R L Gallo
Journal:  Nature       Date:  2001-11-22       Impact factor: 49.962

5.  Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense.

Authors:  C L Wilson; A J Ouellette; D P Satchell; T Ayabe; Y S López-Boado; J L Stratman; S J Hultgren; L M Matrisian; W C Parks
Journal:  Science       Date:  1999-10-01       Impact factor: 47.728

6.  Burkholderia is highly resistant to human Beta-defensin 3.

Authors:  Hany Sahly; Sabine Schubert; Jürgen Harder; Peter Rautenberg; Uwe Ullmann; Jens Schröder; Rainer Podschun
Journal:  Antimicrob Agents Chemother       Date:  2003-05       Impact factor: 5.191

7.  Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic.

Authors:  J Harder; J Bartels; E Christophers; J M Schroder
Journal:  J Biol Chem       Date:  2000-11-20       Impact factor: 5.157

8.  Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes.

Authors:  Ichiro Nomura; Elena Goleva; Michael D Howell; Quatyba A Hamid; Peck Y Ong; Clifton F Hall; Marc A Darst; Bifeng Gao; Mark Boguniewicz; Jeffrey B Travers; Donald Y M Leung
Journal:  J Immunol       Date:  2003-09-15       Impact factor: 5.422

9.  Differential gene induction of human beta-defensins (hBD-1, -2, -3, and -4) in keratinocytes is inhibited by retinoic acid.

Authors:  Jürgen Harder; Ulf Meyer-Hoffert; Kai Wehkamp; Lars Schwichtenberg; Jens-Michael Schröder
Journal:  J Invest Dermatol       Date:  2004-09       Impact factor: 8.551

10.  Analysis and separation of residues important for the chemoattractant and antimicrobial activities of beta-defensin 3.

Authors:  Karen Taylor; David J Clarke; Bryan McCullough; Wutharath Chin; Emily Seo; De Yang; Joost Oppenheim; Dusan Uhrin; John R W Govan; Dominic J Campopiano; Derek MacMillan; Perdita Barran; Julia R Dorin
Journal:  J Biol Chem       Date:  2008-01-07       Impact factor: 5.157
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  25 in total

1.  Peptide fragments of a beta-defensin derivative with potent bactericidal activity.

Authors:  Natalie L Reynolds; Martin De Cecco; Karen Taylor; Chloe Stanton; Fiona Kilanowski; Jason Kalapothakis; Emily Seo; Dusan Uhrin; Dominic Campopiano; John Govan; Derek Macmillan; Perdita Barran; Julia R Dorin
Journal:  Antimicrob Agents Chemother       Date:  2010-02-22       Impact factor: 5.191

2.  Interleukin-17A (IL-17A) and IL-17F Are Critical for Antimicrobial Peptide Production and Clearance of Staphylococcus aureus Nasal Colonization.

Authors:  Nathan K Archer; Nithin D Adappa; James N Palmer; Noam A Cohen; Jan M Harro; Steven K Lee; Lloyd S Miller; Mark E Shirtliff
Journal:  Infect Immun       Date:  2016-11-18       Impact factor: 3.441

Review 3.  G.I. pros: Antimicrobial defense in the gastrointestinal tract.

Authors:  Lawton K Chung; Manuela Raffatellu
Journal:  Semin Cell Dev Biol       Date:  2018-02-12       Impact factor: 7.727

4.  Roles of human beta-defensins in innate immune defense at the ocular surface: arming and alarming corneal and conjunctival epithelial cells.

Authors:  Fabian Garreis; Thomas Schlorf; Dieter Worlitzsch; Philipp Steven; Lars Bräuer; Kristin Jäger; Friedrich P Paulsen
Journal:  Histochem Cell Biol       Date:  2010-06-05       Impact factor: 4.304

5.  Defensins attenuate cytokine responses yet enhance antibody responses to Porphyromonas gingivalis adhesins in mice.

Authors:  Karl G Kohlgraf; Abbey Ackermann; Xiaoying Lu; Kindra Burnell; Myriam Bélanger; Joseph E Cavanaugh; Hua Xie; Ann Progulske-Fox; Kim A Brogden
Journal:  Future Microbiol       Date:  2010-01       Impact factor: 3.165

6.  Clonal Vγ6+Vδ4+ T cells promote IL-17-mediated immunity against Staphylococcus aureus skin infection.

Authors:  Mark C Marchitto; Carly A Dillen; Haiyun Liu; Robert J Miller; Nathan K Archer; Roger V Ortines; Martin P Alphonse; Alina I Marusina; Alexander A Merleev; Yu Wang; Bret L Pinsker; Angel S Byrd; Isabelle D Brown; Advaitaa Ravipati; Emily Zhang; Shuting S Cai; Nathachit Limjunyawong; Xinzhong Dong; Michael R Yeaman; Scott I Simon; Wei Shen; Scott K Durum; Rebecca L O'Brien; Emanual Maverakis; Lloyd S Miller
Journal:  Proc Natl Acad Sci U S A       Date:  2019-05-14       Impact factor: 11.205

7.  β-Defensin 1 plays a role in acute mucosal defense against Candida albicans.

Authors:  Jeffrey Tomalka; Elaheh Azodi; Hema P Narra; Krupen Patel; Samantha O'Neill; Cisley Cardwell; Brian A Hall; James M Wilson; Amy G Hise
Journal:  J Immunol       Date:  2015-01-16       Impact factor: 5.422

8.  CCR6 regulation of the actin cytoskeleton orchestrates human beta defensin-2- and CCL20-mediated restitution of colonic epithelial cells.

Authors:  Rebecca A Vongsa; Noah P Zimmerman; Michael B Dwinell
Journal:  J Biol Chem       Date:  2009-02-20       Impact factor: 5.157

9.  Molecular diversity of the antimicrobial domain of beta-defensin 3 and homologous peptides.

Authors:  Gerardo M Nava; Magdalena Escorcia; M Pilar Castañeda
Journal:  Comp Funct Genomics       Date:  2009-11-02

10.  Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells.

Authors:  Johann Röhrl; De Yang; Joost J Oppenheim; Thomas Hehlgans
Journal:  J Biol Chem       Date:  2010-01-12       Impact factor: 5.157
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