| Literature DB >> 16434190 |
Weigang Huang1, Jingya Li, Wei Zhang, Yueyang Zhou, Chuanming Xie, Yu Luo, Yunfei Li, Jingli Wang, Jia Li, Wei Lu.
Abstract
Miltirone analogues were synthesized and evaluated for inhibitory activity against Cdc25 and PTP1B. Most of the compounds demonstrated potent Cdc25 inhibitory activity, and several exhibited higher selectivity for Cdc25 than for PTP1B. In a cytotoxic assay, most of the compounds displayed cytotoxicity against the tumor cell lines A549 and HCT-116, producing IC(50) values in the micromolar range.Entities:
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Year: 2006 PMID： 16434190 DOI： 10.1016/j.bmcl.2005.12.080
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823