| Literature DB >> 35458583 |
Ahmed Bakr Abdelwahab1, Eslam Reda El-Sawy2, Atef G Hanna2, Denyse Bagrel3, Gilbert Kirsch4.
Abstract
Cdc25 phosphatases have been considered promising targets for anticancer development due to the correlation of their overexpression with a wide variety of cancers. In the last two decades, the interest in this subject has considerably increased and many publications have been launched concerning this issue. An overview is constructed based on data analysis of the results of the previous publications covering the years from 1992 to 2021. Thus, the main objective of the current review is to report the chemical structures of Cdc25s inhibitors and answer the question, how to design an inhibitor with better efficacy and lower toxicity?Entities:
Keywords: Cdc25 phosphatases; computational technique; glycoside; inhibitor; quinoid; steroid
Mesh：
Substances：
Year: 2022 PMID： 35458583 PMCID： PMC9031484 DOI： 10.3390/molecules27082389
Source DB: PubMed Journal: Molecules ISSN： 1420-3049 Impact factor: 4.927