Literature DB >> 16432518

BEAMing up for detection and quantification of rare sequence variants.

Meng Li1, Frank Diehl, Devin Dressman, Bert Vogelstein, Kenneth W Kinzler.   

Abstract

BEAMing allows the one-to-one conversion of a population of DNA fragments into a population of beads. We used rolling circle amplification to increase the number of copies bound to such beads by more than 100-fold. This allowed enumeration of mutant and wild-type sequences even when they were present at ratios less than 1:10,000 and was sensitive enough to directly quantify the error rate of DNA polymerases used for PCR.

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Year:  2006        PMID： 16432518     DOI： 10.1038/nmeth850

Source DB:  PubMed          Journal:  Nat Methods        ISSN： 1548-7091            Impact factor:   28.547


  94 in total

1.  Screening for ovarian cancer: imaging challenges and opportunities for improvement.

Authors:  K B Mathieu; D G Bedi; S L Thrower; A Qayyum; R C Bast
Journal:  Ultrasound Obstet Gynecol       Date:  2018-03       Impact factor: 7.299

Review 2.  Droplet microfluidics for high-sensitivity and high-throughput detection and screening of disease biomarkers.

Authors:  Aniruddha M Kaushik; Kuangwen Hsieh; Tza-Huei Wang
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2018-05-24

Review 3.  The challenges of sequencing by synthesis.

Authors:  Carl W Fuller; Lyle R Middendorf; Steven A Benner; George M Church; Timothy Harris; Xiaohua Huang; Stevan B Jovanovich; John R Nelson; Jeffery A Schloss; David C Schwartz; Dmitri V Vezenov
Journal:  Nat Biotechnol       Date:  2009-11-06       Impact factor: 54.908

4.  Megapixel digital PCR.

Authors:  Kevin A Heyries; Carolina Tropini; Michael Vaninsberghe; Callum Doolin; Oleh I Petriv; Anupam Singhal; Kaston Leung; Curtis B Hughesman; Carl L Hansen
Journal:  Nat Methods       Date:  2011-07-03       Impact factor: 28.547

5.  Detection of circulating tumor DNA in early- and late-stage human malignancies.

Authors:  Chetan Bettegowda; Mark Sausen; Rebecca J Leary; Isaac Kinde; Yuxuan Wang; Nishant Agrawal; Bjarne R Bartlett; Hao Wang; Brandon Luber; Rhoda M Alani; Emmanuel S Antonarakis; Nilofer S Azad; Alberto Bardelli; Henry Brem; John L Cameron; Clarence C Lee; Leslie A Fecher; Gary L Gallia; Peter Gibbs; Dung Le; Robert L Giuntoli; Michael Goggins; Michael D Hogarty; Matthias Holdhoff; Seung-Mo Hong; Yuchen Jiao; Hartmut H Juhl; Jenny J Kim; Giulia Siravegna; Daniel A Laheru; Calogero Lauricella; Michael Lim; Evan J Lipson; Suely Kazue Nagahashi Marie; George J Netto; Kelly S Oliner; Alessandro Olivi; Louise Olsson; Gregory J Riggins; Andrea Sartore-Bianchi; Kerstin Schmidt; le-Ming Shih; Sueli Mieko Oba-Shinjo; Salvatore Siena; Dan Theodorescu; Jeanne Tie; Timothy T Harkins; Silvio Veronese; Tian-Li Wang; Jon D Weingart; Christopher L Wolfgang; Laura D Wood; Dongmei Xing; Ralph H Hruban; Jian Wu; Peter J Allen; C Max Schmidt; Michael A Choti; Victor E Velculescu; Kenneth W Kinzler; Bert Vogelstein; Nickolas Papadopoulos; Luis A Diaz
Journal:  Sci Transl Med       Date:  2014-02-19       Impact factor: 17.956

6.  Mutational evidence for a structural model of the Lassa virus RNA polymerase domain and identification of two residues, Gly1394 and Asp1395, that are critical for transcription but not replication of the genome.

Authors:  Meike Hass; Michaela Lelke; Carola Busch; Beate Becker-Ziaja; Stephan Günther
Journal:  J Virol       Date:  2008-07-30       Impact factor: 5.103

7.  Selection of bead-displayed, PNA-encoded chemicals.

Authors:  Natalie R Gassman; J Patrick Nelli; Samrat Dutta; Adam Kuhn; Keith Bonin; Zbigniew Pianowski; Nicolas Winssinger; Martin Guthold; Jed C Macosko
Journal:  J Mol Recognit       Date:  2010 Sep-Oct       Impact factor: 2.137

8.  Product length, dye choice, and detection chemistry in the bead-emulsion amplification of millions of single DNA molecules in parallel.

Authors:  Irene Tiemann-Boege; Christina Curtis; Deepali N Shinde; Daniel B Goodman; Simon Tavaré; Norman Arnheim
Journal:  Anal Chem       Date:  2009-07-15       Impact factor: 6.986

9.  Circulating mutant DNA to assess tumor dynamics.

Authors:  Frank Diehl; Kerstin Schmidt; Michael A Choti; Katharine Romans; Steven Goodman; Meng Li; Katherine Thornton; Nishant Agrawal; Lori Sokoll; Steve A Szabo; Kenneth W Kinzler; Bert Vogelstein; Luis A Diaz
Journal:  Nat Med       Date:  2007-07-31       Impact factor: 53.440

10.  Analysis of cancer mutation signatures in blood by a novel ultra-sensitive assay: monitoring of therapy or recurrence in non-metastatic breast cancer.

Authors:  Zhenbin Chen; Jinong Feng; Carolyn H Buzin; Qiang Liu; Lawrence Weiss; Kemp Kernstine; George Somlo; Steve S Sommer
Journal:  PLoS One       Date:  2009-09-28       Impact factor: 3.240
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