Literature DB >> 16428831

Identification and analysis of Ku70 and Ku80 homologs in the koji molds Aspergillus sojae and Aspergillus oryzae.

Tadashi Takahashi1, Tsutomu Masuda, Yasuji Koyama.   

Abstract

Ku genes play a key role in the non-homologous end-joining pathway. We have identified Ku70 and Ku80 homologs in the koji molds Aspergillus sojae and Aspergillus oryzae, and have constructed the disruption mutants of Ku70, Ku80, and Ku70-80 to characterize the phenotypic change in these mutants. Neither Ku70- nor Ku80-disrupted strains show hypersensitivity to the DNA damaging agents methylmethane sulfonate (MMS) and phleomycin. Moreover, undesirable phenotypes, such as poor growth or repressed conidiospore formation, were not observed in the Ku-disrupted A. sojae and A. oryzae.

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Year:  2006        PMID： 16428831     DOI： 10.1271/bbb.70.135

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  15 in total

1.  Comparison of the paralogous transcription factors AraR and XlnR in Aspergillus oryzae.

Authors:  Kana Ishikawa; Emi Kunitake; Tomomi Kawase; Motoki Atsumi; Yuji Noguchi; Shuhei Ishikawa; Masahiro Ogawa; Yasuji Koyama; Makoto Kimura; Kyoko Kanamaru; Masashi Kato; Tetsuo Kobayashi
Journal:  Curr Genet       Date:  2018-04-13       Impact factor: 3.886

2.  Ku80 gene is related to non-homologous end-joining and genome stability in Aspergillus niger.

Authors:  Jinxiang Zhang; Zhihui Mao; Wei Xue; Ying Li; Guomin Tang; Aoquan Wang; Yingjiu Zhang; Huaming Wang
Journal:  Curr Microbiol       Date:  2011-01-12       Impact factor: 2.188

3.  Identification of a gene involved in the synthesis of a dipeptidyl peptidase IV inhibitor in Aspergillus oryzae.

Authors:  Kazuhiko Imamura; Yoshihito Tsuyama; Terukage Hirata; Sumihiro Shiraishi; Kazutoshi Sakamoto; Osamu Yamada; Osamu Akita; Hitoshi Shimoi
Journal:  Appl Environ Microbiol       Date:  2012-07-27       Impact factor: 4.792

4.  Targeted tandem duplication of a large chromosomal segment in Aspergillus oryzae.

Authors:  Tadashi Takahashi; Atsushi Sato; Masahiro Ogawa; Yoshiki Hanya; Tetsuya Oguma
Journal:  Appl Environ Microbiol       Date:  2014-08       Impact factor: 4.792

Review 5.  Advances in Aspergillus secondary metabolite research in the post-genomic era.

Authors:  James F Sanchez; Amber D Somoza; Nancy P Keller; Clay C C Wang
Journal:  Nat Prod Rep       Date:  2012-01-06       Impact factor: 13.423

6.  Deletion of ku homologs increases gene targeting frequency in Streptomyces avermitilis.

Authors:  Xiaojuan Zhang; Wei Chen; Yang Zhang; Libin Jiang; Zhi Chen; Ying Wen; Jilun Li
Journal:  J Ind Microbiol Biotechnol       Date:  2012-02-21       Impact factor: 3.346

7.  Molecular characterization of DNA repair protein Ku70 from Vitis vinifera and its purification from transgenic tobacco.

Authors:  Himanshu Tak; Minal Mhatre
Journal:  Transgenic Res       Date:  2013-01-30       Impact factor: 2.788

8.  Enhanced gene targeting frequency in ku70 and ku80 disruption mutants of Aspergillus sojae and Aspergillus oryzae.

Authors:  Tadashi Takahashi; Tsutomu Masuda; Yasuji Koyama
Journal:  Mol Genet Genomics       Date:  2006-02-10       Impact factor: 3.291

9.  Endocytosis is crucial for cell polarity and apical membrane recycling in the filamentous fungus Aspergillus oryzae.

Authors:  Yujiro Higuchi; Jun-ya Shoji; Manabu Arioka; Katsuhiko Kitamoto
Journal:  Eukaryot Cell       Date:  2008-11-21

10.  Deletion of the Pichia pastoris KU70 homologue facilitates platform strain generation for gene expression and synthetic biology.

Authors:  Laura Näätsaari; Beate Mistlberger; Claudia Ruth; Tanja Hajek; Franz S Hartner; Anton Glieder
Journal:  PLoS One       Date:  2012-06-29       Impact factor: 3.240
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