| Literature DB >> 16413548 |
Christopher L Brett1, Mark Donowitz, Rajini Rao.
Abstract
Inherent to the proteome itself, may be information that enables proteins to buffer pH at a level that promotes their own function within a specialized compartment. We observe that the distribution of computed isoelectric points in the yeast proteome matches experimentally derived organellar pH estimates across distinct subcellular compartments. This raises an interesting evolutionary question: did the pI of proteins and the pH of organelles co-evolve to optimize function?Entities:
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Year: 2006 PMID： 16413548 DOI： 10.1016/j.febslet.2005.12.103
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124