Literature DB >> 16412984

Empirical antibacterial drug discovery--foundation in natural products.

Sheo B Singh1, John F Barrett.   

Abstract

Natural products have been a rich source in providing leads for the development of drugs for the treatment of bacterial infections. However, beyond the discovery of the natural product, thienamycin and the synthetic lead, oxazolidinone in the 1970s, there has been a dearth of new compounds. This commentary provides an overview of current antibiotic leads and their mechanism of action, and highlights tools that can be applied to the discovery of new antibiotics.

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Year:  2006        PMID： 16412984     DOI： 10.1016/j.bcp.2005.12.016

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  32 in total

1.  Motualevic acids and analogs: synthesis and antimicrobial structure-activity relationships.

Authors:  Pradeep Cheruku; Jessica L Keffer; Cajetan Dogo-Isonagie; Carole A Bewley
Journal:  Bioorg Med Chem Lett       Date:  2010-06-09       Impact factor: 2.823

2.  Antimicrobial activity of Alcaligenes sp. HPC 1271 against multidrug resistant bacteria.

Authors:  Atya Kapley; Himgouri Tanksale; Sneha Sagarkar; A R Prasad; Rathod Aravind Kumar; Nandita Sharma; Asifa Qureshi; Hemant J Purohit
Journal:  Funct Integr Genomics       Date:  2015-10-02       Impact factor: 3.410

Review 3.  Recent advances in the chemistry and biology of naturally occurring antibiotics.

Authors:  K C Nicolaou; Jason S Chen; David J Edmonds; Anthony A Estrada
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

4.  Integrated Genomic and Functional Characterization of the Anti-diabetic Potential of Arthrobacter sp. SW1.

Authors:  Shraddha Shaligram; Nitin P Narwade; Shreyas V Kumbhare; Manobjyoti Bordoloi; Kashyap J Tamuli; Shyamalendu Nath; T Parimelazhagan; Vikas S Patil; Atya Kapley; Shrikant P Pawar; Dhiraj P Dhotre; M G Muddeshwar; Hemant J Purohit; Yogesh S Shouche
Journal:  Curr Microbiol       Date:  2021-05-13       Impact factor: 2.188

Review 5.  Novel classes of antibiotics or more of the same?

Authors:  Anthony R M Coates; Gerry Halls; Yanmin Hu
Journal:  Br J Pharmacol       Date:  2011-05       Impact factor: 8.739

6.  Kibdelomycin is a bactericidal broad-spectrum aerobic antibacterial agent.

Authors:  Sheo B Singh; Priya Dayananth; Carl J Balibar; Charles G Garlisi; Jun Lu; Ryuta Kishii; Masaya Takei; Yasumichi Fukuda; Sookhee Ha; Katherine Young
Journal:  Antimicrob Agents Chemother       Date:  2015-04-06       Impact factor: 5.191

7.  In 2035, will all bacteria be multiresistant? Yes.

Authors:  George Dimopoulos; Marin H Kollef; Jon Cohen
Journal:  Intensive Care Med       Date:  2016-04-18       Impact factor: 17.440

Review 8.  Development of novel drugs from marine surface associated microorganisms.

Authors:  Anahit Penesyan; Staffan Kjelleberg; Suhelen Egan
Journal:  Mar Drugs       Date:  2010-03-01       Impact factor: 5.118

9.  Activity and interactions of antibiotic and phytochemical combinations against Pseudomonas aeruginosa in vitro.

Authors:  Premkumar Jayaraman; Meena K Sakharkar; Chu Sing Lim; Thean Hock Tang; Kishore R Sakharkar
Journal:  Int J Biol Sci       Date:  2010-09-21       Impact factor: 6.580

10.  Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.

Authors:  Jun Wang; Srinivas Kodali; Sang Ho Lee; Andrew Galgoci; Ronald Painter; Karen Dorso; Fred Racine; Mary Motyl; Lorraine Hernandez; Elizabeth Tinney; Steven L Colletti; Kithsiri Herath; Richard Cummings; Oscar Salazar; Ignacio González; Angela Basilio; Francisca Vicente; Olga Genilloud; Fernando Pelaez; Hiranthi Jayasuriya; Katherine Young; Doris F Cully; Sheo B Singh
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-24       Impact factor: 11.205
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