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Literature DB >> 20538459

Motualevic acids and analogs: synthesis and antimicrobial structure-activity relationships.

Pradeep Cheruku¹, Jessica L Keffer, Cajetan Dogo-Isonagie, Carole A Bewley.

Abstract

Synthesis of the marine natural products motualevic acids A, E, and analogs in which modifications have been made to the omega-brominated lipid (E)-14,14-dibromotetra-deca-2,13-dienoic acid or amino acid unit are reported, together with antimicrobial activities against Staphylococcus aureus, methicillin-resistant S. aureus, Enterococcus faecium, and vancomycin-resistant Enterococcus. Published by Elsevier Ltd.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20538459 PMCID： PMC2900419 DOI： 10.1016/j.bmcl.2010.05.073

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

15 in total

1. Daptomycin.

Authors: Peter Kirkpatrick; Aarti Raja; Jason LaBonte; John Lebbos
Journal: Nat Rev Drug Discov Date: 2003-12 Impact factor: 84.694

2. Introduction: antibiotic resistance.

Authors: Christopher Walsh; Gerard Wright
Journal: Chem Rev Date: 2005-02 Impact factor: 60.622

Review 3. Drugs for bad bugs: confronting the challenges of antibacterial discovery.

Authors: David J Payne; Michael N Gwynn; David J Holmes; David L Pompliano
Journal: Nat Rev Drug Discov Date: 2006-12-08 Impact factor: 84.694

Review 4. Empirical antibacterial drug discovery--foundation in natural products.

Authors: Sheo B Singh; John F Barrett
Journal: Biochem Pharmacol Date: 2006-01-19 Impact factor: 5.858

5. Synthesis of marine polyacetylenes callyberynes A-C by transition-metal-catalyzed cross-coupling reactions to sp centers.

Authors: Susana López; Francisco Fernandez-Trillo; Pilar Midón; Luis Castedo; Carlos Saa
Journal: J Org Chem Date: 2006-03-31 Impact factor: 4.354

Review 6. Oxazolidinone structure-activity relationships leading to linezolid.

Authors: Michael R Barbachyn; Charles W Ford
Journal: Angew Chem Int Ed Engl Date: 2003-05-09 Impact factor: 15.336

Review 7. Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections.

Authors: Steven J Brickner; Michael R Barbachyn; Douglas K Hutchinson; Peter R Manninen
Journal: J Med Chem Date: 2008-03-14 Impact factor: 7.446

Motualevic acids and analogs: synthesis and antimicrobial structure-activity relationships.

1. Daptomycin.

2. Introduction: antibiotic resistance.

Review 3. Drugs for bad bugs: confronting the challenges of antibacterial discovery.

Review 4. Empirical antibacterial drug discovery--foundation in natural products.

5. Synthesis of marine polyacetylenes callyberynes A-C by transition-metal-catalyzed cross-coupling reactions to sp centers.

Review 6. Oxazolidinone structure-activity relationships leading to linezolid.

Review 7. Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections.

8. Trends in infectious diseases mortality in the United States.

9. Development of a concise and diversity-oriented approach for the synthesis of plecomacrolides via the diene-ene RCM.

10. Motualevic acids A-F, antimicrobial acids from the sponge Siliquariaspongia sp.

Review 1. Light opens a new window for N-heterocyclic carbene catalysis.