BACKGROUND: Maternal ageing is the only aetiological factor unequivocally linked to aneuploidy. Two mechanisms seem to explain these abnormalities in oocytes: non-disjunction and premature unbalanced separation of sister chromatids (PSSC). Previous studies of unfertilized oocytes argue for a major role of PSSC in the aetiology of aneuploidy for women of advanced age, but in vitro ageing of the oocytes could influence the results. METHODS: Owing to the high prevalence of aneuploidy in women of advanced age, chromosomal screening of the first polar body just before ICSI was offered to women (from 38 years of age) included in an assisted reproduction programme. RESULTS: Among 141 oocytes from 29 women (mean age 40 years and 2 months), 43 (30.5%) were abnormal. Sixty-five abnormalities were found and PSSC was involved in 80% of cases. CONCLUSION: These results are in accordance with previous studies and confirm, in 'fresh' oocytes, the major role of PSSC in the aetiology of aneuploidy in women of advanced age.
BACKGROUND: Maternal ageing is the only aetiological factor unequivocally linked to aneuploidy. Two mechanisms seem to explain these abnormalities in oocytes: non-disjunction and premature unbalanced separation of sister chromatids (PSSC). Previous studies of unfertilized oocytes argue for a major role of PSSC in the aetiology of aneuploidy for women of advanced age, but in vitro ageing of the oocytes could influence the results. METHODS: Owing to the high prevalence of aneuploidy in women of advanced age, chromosomal screening of the first polar body just before ICSI was offered to women (from 38 years of age) included in an assisted reproduction programme. RESULTS: Among 141 oocytes from 29 women (mean age 40 years and 2 months), 43 (30.5%) were abnormal. Sixty-five abnormalities were found and PSSC was involved in 80% of cases. CONCLUSION: These results are in accordance with previous studies and confirm, in 'fresh' oocytes, the major role of PSSC in the aetiology of aneuploidy in women of advanced age.
Authors: Teresa Chiang; Francesca E Duncan; Karen Schindler; Richard M Schultz; Michael A Lampson Journal: Curr Biol Date: 2010-09-14 Impact factor: 10.834
Authors: I Hammoud; F Vialard; M Bergere; M Albert; D Molina Gomes; M Adler; L Malagrida; M Bailly; R Wainer; J Selva Journal: J Assist Reprod Genet Date: 2012-08-14 Impact factor: 3.412
Authors: L Gianaroli; M C Magli; G Cavallini; A Crippa; A Capoti; S Resta; F Robles; A P Ferraretti Journal: Hum Reprod Date: 2010-07-08 Impact factor: 6.918
Authors: Shawn Leland; Prabakaran Nagarajan; Aris Polyzos; Sharon Thomas; George Samaan; Robert Donnell; Francesco Marchetti; Sundaresan Venkatachalam Journal: Proc Natl Acad Sci U S A Date: 2009-07-17 Impact factor: 11.205