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Literature DB >> 164018

Methylated nucleotides block 5'-terminus of vaccinia virus messenger RNA.

Abstract

Studies on the nature and location of the methylated nucleotides in mRNA synthesized in vitro by vaccinia virus particles revealed an unusual 5'-terminal structure. Evidence that the pyrophosphate group is blocked by 7-methylguanosine and that both 2'-O-methyl-adenosine and 2'-O-methylguanosine occupy penultimate positions was presented. According to this model, the 5'-termini of vaccinia virus mRNAs are: 7MeG-5'ppp-5'GMepNp and 7MeG-5'AMepNp.

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Year: 1975 PMID： 164018 PMCID： PMC432296 DOI： 10.1073/pnas.72.1.318

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

7 in total

1. "Methylation-coupled" transcription by virus-associated transcriptase of cytoplasmic polyhedrosis virus containing double-stranded RNA.

Authors: Y Furuichi
Journal: Nucleic Acids Res Date: 1974-06 Impact factor: 16.971

2. 5'-Terminal nucleotide sequences of the double-stranded RNA of silkworm cytoplasmic polyhedrosis virus.

Authors: K Miura; K Watanabe; M Sugiura
Journal: J Mol Biol Date: 1974-06-15 Impact factor: 5.469

3. The 5'-terminal nucleotide sequences of the double-stranded RNA of human reovirus.

Authors: K Miura; K Watanabe; M Sugiura; A J Shatkin
Journal: Proc Natl Acad Sci U S A Date: 1974-10 Impact factor: 11.205

4. Methylated messenger RNA synthesis in vitro by purified reovirus.

Authors: A J Shatkin
Journal: Proc Natl Acad Sci U S A Date: 1974-08 Impact factor: 11.205

5. Transfer ribonucleic acid methylases of HeLa cells.

Authors: L A Culp; G M Brown
Journal: Arch Biochem Biophys Date: 1968-03-20 Impact factor: 4.013

6. Ribonucleic acid synthesis in vaccinia virus. I. The mechanism of synthesis and release of RNA in vaccinia cores.

Authors: J Kates; J Beeson
Journal: J Mol Biol Date: 1970-05-28 Impact factor: 5.469

7. Methylation of newly synthesized viral messenger RNA by an enzyme in vaccinia virus.

Authors: C M Wei; B Moss
Journal: Proc Natl Acad Sci U S A Date: 1974-08 Impact factor: 11.205

7 in total

129 in total

10. Poxvirus decapping enzymes enhance virulence by preventing the accumulation of dsRNA and the induction of innate antiviral responses.

Authors: Shin-Wu Liu; George C Katsafanas; Ruikang Liu; Linda S Wyatt; Bernard Moss
Journal: Cell Host Microbe Date: 2015-03-11 Impact factor: 21.023

Methylated nucleotides block 5'-terminus of vaccinia virus messenger RNA.

1. "Methylation-coupled" transcription by virus-associated transcriptase of cytoplasmic polyhedrosis virus containing double-stranded RNA.

2. 5'-Terminal nucleotide sequences of the double-stranded RNA of silkworm cytoplasmic polyhedrosis virus.

3. The 5'-terminal nucleotide sequences of the double-stranded RNA of human reovirus.

4. Methylated messenger RNA synthesis in vitro by purified reovirus.

5. Transfer ribonucleic acid methylases of HeLa cells.

6. Ribonucleic acid synthesis in vaccinia virus. I. The mechanism of synthesis and release of RNA in vaccinia cores.

7. Methylation of newly synthesized viral messenger RNA by an enzyme in vaccinia virus.

1. Influenza viral mRNA contains internal N6-methyladenosine and 5'-terminal 7-methylguanosine in cap structures.

2. E.B. Wilson Lecture, 1998. Eukaryotic RNAs: once more from the beginning.

3. m7G5'ppp5'GmptcpUp at the 5' terminus of reovirus messenger RNA.

Review 4. An unconventional pathway of mRNA cap formation by vesiculoviruses.

5. Reverse genetics analysis of poxvirus intermediate transcription factors.

6. Viruses know more than one way to don a cap.

7. Cell-free translation of purified virion-associated high-molecular-weight RNA synthesized in vitro by vaccinia virus.

8. Inhibition of initiation of protein synthesis by 7-methylguanosine-5'-monophosphate.

9. Synthesis of RNA containing a methylated blocked 5' terminus by HeLa nuclear homogenates.

10. Poxvirus decapping enzymes enhance virulence by preventing the accumulation of dsRNA and the induction of innate antiviral responses.