Riva Tauman1,2, Shlomit Shalitin3,4, Lena Lavie5. 1. Sleep Disorders Center, Tel Aviv Medical Center, 6 Weizmann Street, 6423906, Tel Aviv, Israel. tauman@tlvmc.gov.il. 2. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. tauman@tlvmc.gov.il. 3. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. 4. The Jesse Z. and Lea Shafer Institute of Endocrinology and Diabetes, Schneider Children's Medical Center of Israel, Petach Tikva, Israel. 5. Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Abstract
PURPOSE: Obesity, obstructive sleep apnea (OSA), and type 2 diabetes mellitus (T2DM) are associated with chronic low-grade inflammation and oxidative stress. In adults, increased lipid peroxidation, a marker of oxidative stress, was found in both metabolic syndrome and OSA. Studies on oxidative stress in children with T2DM and OSA are scarce. METHODS: Plasma oxidized low-density lipoprotein (Ox-LDL) levels were evaluated in obese children and adolescents with/without T2DM, and the contribution of OSA to oxidative stress was investigated. RESULTS: Ten patients with T2DM, 8 with impaired glucose tolerance (IGT), and 20 body mass index-standard deviation score (BMI-SDS)-matched non-diabetic children (controls) were studied. They all underwent overnight polysomnography. Fasting plasma concentrations of Ox-LDL were measured and compared to the glycemic status and to the presence of OSA. Fourteen patients (36%) were diagnosed with OSA and 21 (55%) with hypertension. There were no significant group differences in plasma Ox-LDL levels or between patients with/without OSA. Plasma Ox-LDL levels were significantly higher among patients with hypertension compared to controls (P = 0.01), while they correlated with homeostasis model assessment (P = 0.02), BMI-SDS (P = 0.049), and systolic blood pressure (P = 0.002). CONCLUSIONS: The findings of this pilot study suggest that increased lipid peroxidation is associated with insulin resistance and hypertension in obese children and adolescents, while OSA has most likely minor influence.
PURPOSE: Obesity, obstructive sleep apnea (OSA), and type 2 diabetes mellitus (T2DM) are associated with chronic low-grade inflammation and oxidative stress. In adults, increased lipid peroxidation, a marker of oxidative stress, was found in both metabolic syndrome and OSA. Studies on oxidative stress in children with T2DM and OSA are scarce. METHODS: Plasma oxidized low-density lipoprotein (Ox-LDL) levels were evaluated in obesechildren and adolescents with/without T2DM, and the contribution of OSA to oxidative stress was investigated. RESULTS: Ten patients with T2DM, 8 with impaired glucose tolerance (IGT), and 20 body mass index-standard deviation score (BMI-SDS)-matched non-diabeticchildren (controls) were studied. They all underwent overnight polysomnography. Fasting plasma concentrations of Ox-LDL were measured and compared to the glycemic status and to the presence of OSA. Fourteen patients (36%) were diagnosed with OSA and 21 (55%) with hypertension. There were no significant group differences in plasma Ox-LDL levels or between patients with/without OSA. Plasma Ox-LDL levels were significantly higher among patients with hypertension compared to controls (P = 0.01), while they correlated with homeostasis model assessment (P = 0.02), BMI-SDS (P = 0.049), and systolic blood pressure (P = 0.002). CONCLUSIONS: The findings of this pilot study suggest that increased lipid peroxidation is associated with insulin resistance and hypertension in obesechildren and adolescents, while OSA has most likely minor influence.
Authors: Vlady Ostrow; Shufang Wu; Alexandra Aguilar; Robert Bonner; Elizabeth Suarez; Francesco De Luca Journal: J Pediatr Date: 2011-04 Impact factor: 4.406
Authors: Paul Holvoet; Nancy S Jenny; Pamela J Schreiner; Russell P Tracy; David R Jacobs Journal: Atherosclerosis Date: 2006-09-18 Impact factor: 5.162
Authors: Anne L Norris; Julia Steinberger; Lyn M Steffen; Andrea M Metzig; Sarah Jane Schwarzenberg; Aaron S Kelly Journal: Obesity (Silver Spring) Date: 2011-02-17 Impact factor: 5.002
Authors: Mona H Sedeek; Maria T Llinas; Heather Drummond; Lourdes Fortepiani; Sean R Abram; Barbara T Alexander; Jane F Reckelhoff; Joey P Granger Journal: Hypertension Date: 2003-07-21 Impact factor: 10.190
Authors: Aaron S Kelly; David R Jacobs; Alan R Sinaiko; Antoinette Moran; Lyn M Steffen; Julia Steinberger Journal: Pediatr Diabetes Date: 2010-12 Impact factor: 4.866