BACKGROUND: Accumulating evidence suggests a cross-sectional association between oxidative stress and type 2 diabetes (T2D). Systemic oxidative stress, as measured by oxidized LDL (oxLDL), has been correlated with visceral fat. We examined the relationship between oxLDL, and T2D- and obesity-related traits in a bi-racial sample of 2985 subjects at baseline and after 7 years of follow-up. METHODS: We examined six T2D-related traits (T2D status, HbA(1c), fasting glucose, insulin, adiponectin and HOMA-IR) as well as six obesity-related traits (obesity status, BMI, leptin, % body fat, visceral and subcutaneous fat mass) using logistic and linear regression models. RESULTS: In all subjects at baseline, oxLDL was positively associated with T2D (OR = 1.3, 95% CI:1.1-1.5), fasting glucose (ss = 0.03 +/- 0.006), HbA(1c) (ss = 0.02 +/- 0.004), fasting insulin (ss = 0.12 +/- 0.02), HOMA-IR (ss = 0.13 +/- 0.02) and negatively with adiponectin (ss = -0.16 +/- 0.03), (all p < 0.001). The strength and magnitude of these associations did not differ much between blacks and whites. In both blacks and whites, oxLDL was also associated with obesity (OR = 1.3, 95% CI:1.1-1.4) and three of its related traits (ss = 0.60 +/- 0.14 for BMI, ss = 0.74 +/- 0.17 for % body fat, ss = 0.29 +/- 0.06 for visceral fat; all p < 0.001). Furthermore, of four traits measured after 7 years of follow-up (fasting glucose, HbA1c, BMI and % fat), their relationship with oxLDL was similar to baseline observations. No significant association was found between oxLDL and incident T2D. Interestingly, oxLDL was significantly associated with % change in T2D- and obesity-related traits in whites but not in blacks. CONCLUSION/ INTERPRETATION: Our data suggest that systemic oxidative stress may be a novel risk factor for T2D and obesity.
BACKGROUND: Accumulating evidence suggests a cross-sectional association between oxidative stress and type 2 diabetes (T2D). Systemic oxidative stress, as measured by oxidized LDL (oxLDL), has been correlated with visceral fat. We examined the relationship between oxLDL, and T2D- and obesity-related traits in a bi-racial sample of 2985 subjects at baseline and after 7 years of follow-up. METHODS: We examined six T2D-related traits (T2D status, HbA(1c), fasting glucose, insulin, adiponectin and HOMA-IR) as well as six obesity-related traits (obesity status, BMI, leptin, % body fat, visceral and subcutaneous fat mass) using logistic and linear regression models. RESULTS: In all subjects at baseline, oxLDL was positively associated with T2D (OR = 1.3, 95% CI:1.1-1.5), fasting glucose (ss = 0.03 +/- 0.006), HbA(1c) (ss = 0.02 +/- 0.004), fasting insulin (ss = 0.12 +/- 0.02), HOMA-IR (ss = 0.13 +/- 0.02) and negatively with adiponectin (ss = -0.16 +/- 0.03), (all p < 0.001). The strength and magnitude of these associations did not differ much between blacks and whites. In both blacks and whites, oxLDL was also associated with obesity (OR = 1.3, 95% CI:1.1-1.4) and three of its related traits (ss = 0.60 +/- 0.14 for BMI, ss = 0.74 +/- 0.17 for % body fat, ss = 0.29 +/- 0.06 for visceral fat; all p < 0.001). Furthermore, of four traits measured after 7 years of follow-up (fasting glucose, HbA1c, BMI and % fat), their relationship with oxLDL was similar to baseline observations. No significant association was found between oxLDL and incident T2D. Interestingly, oxLDL was significantly associated with % change in T2D- and obesity-related traits in whites but not in blacks. CONCLUSION/ INTERPRETATION: Our data suggest that systemic oxidative stress may be a novel risk factor for T2D and obesity.
Authors: John F Keaney; Martin G Larson; Ramachandran S Vasan; Peter W F Wilson; Izabella Lipinska; Diane Corey; Joseph M Massaro; Patrice Sutherland; Joseph A Vita; Emelia J Benjamin Journal: Arterioscler Thromb Vasc Biol Date: 2003-01-30 Impact factor: 8.311
Authors: I Lemieux; A Pascot; D Prud'homme; N Alméras; P Bogaty; A Nadeau; J Bergeron; J P Després Journal: Arterioscler Thromb Vasc Biol Date: 2001-06 Impact factor: 8.311
Authors: I Lemieux; A Pascot; C Couillard; B Lamarche; A Tchernof; N Alméras; J Bergeron; D Gaudet; G Tremblay; D Prud'homme; A Nadeau; J P Després Journal: Circulation Date: 2000-07-11 Impact factor: 29.690
Authors: P Holvoet; A Mertens; P Verhamme; K Bogaerts; G Beyens; R Verhaeghe; D Collen; E Muls; F Van de Werf Journal: Arterioscler Thromb Vasc Biol Date: 2001-05 Impact factor: 8.311
Authors: Shijie Li; Paul Kievit; Anna-Karin Robertson; Ganesh Kolumam; Xiumin Li; Karin von Wachenfeldt; Christine Valfridsson; Sherry Bullens; Ilhem Messaoudi; Lindsay Bader; Kyra J Cowan; Amrita Kamath; Nicholas van Bruggen; Stuart Bunting; Björn Frendéus; Kevin L Grove Journal: Mol Metab Date: 2013-06-11 Impact factor: 7.422
Authors: Kamil Borkowski; Sun J Yim; Roberta R Holt; Robert M Hackman; Carl L Keen; John W Newman; Gregory C Shearer Journal: J Nutr Biochem Date: 2019-03-28 Impact factor: 6.048
Authors: Giovanni Zuliani; Mario Luca Morieri; Stefano Volpato; Giovanni B Vigna; Cristina Bosi; Marcello Maggio; Antonio Cherubini; Stefania Bandinelli; Jack M Guralnik; Luigi Ferrucci Journal: Atherosclerosis Date: 2012-10-11 Impact factor: 5.162
Authors: B Van der Schueren; R Vangoitsenhoven; B Geeraert; D De Keyzer; M Hulsmans; M Lannoo; H J Huber; C Mathieu; P Holvoet Journal: Int J Obes (Lond) Date: 2015-04-14 Impact factor: 5.095
Authors: Seth L Masters; Aisling Dunne; Shoba L Subramanian; Rebecca L Hull; Gillian M Tannahill; Fiona A Sharp; Christine Becker; Luigi Franchi; Eiji Yoshihara; Zhe Chen; Niamh Mullooly; Lisa A Mielke; James Harris; Rebecca C Coll; Kingston H G Mills; K Hun Mok; Philip Newsholme; Gabriel Nuñez; Junji Yodoi; Steven E Kahn; Ed C Lavelle; Luke A J O'Neill Journal: Nat Immunol Date: 2010-09-12 Impact factor: 25.606
Authors: Gregory J Tranah; Jennifer S Yokoyama; Shana M Katzman; Michael A Nalls; Anne B Newman; Tamara B Harris; Matteo Cesari; Todd M Manini; Nicholas J Schork; Steven R Cummings; Yongmei Liu; Kristine Yaffe Journal: Neurobiol Aging Date: 2013-10-18 Impact factor: 4.673