Literature DB >> 1639398

Gene-centromere linkage mapping by PCR analysis of individual oocytes.

X Cui1, J Gerwin, W Navidi, H Li, M Kuehn, N Arnheim.   

Abstract

We describe a general method of determining the recombination fraction between a polymorphic locus and the centromere in any species where single oocytes can be obtained. After removal of the first polar body, each oocyte is analyzed by PCR. The frequency of oocytes heterozygous at the polymorphic locus is used to estimate the recombination fraction. We estimate a recombination fraction of 0.15 between the mouse major histocompatibility complex (H-2) and the centromere of chromosome 17.

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Year:  1992        PMID： 1639398     DOI： 10.1016/0888-7543(92)90146-j

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  11 in total

Review 1.  Hot and cold spots of recombination in the human genome: the reason we should find them and how this can be achieved.

Authors:  Norman Arnheim; Peter Calabrese; Magnus Nordborg
Journal:  Am J Hum Genet       Date:  2003-05-22       Impact factor: 11.025

2.  Linkage information content and efficiency of full-sib and half-sib designs for gene mapping.

Authors:  Y Da; H A Lewin
Journal:  Theor Appl Genet       Date:  1995-04       Impact factor: 5.699

3.  Centromere-linkage analysis and consolidation of the zebrafish genetic map.

Authors:  S L Johnson; M A Gates; M Johnson; W S Talbot; S Horne; K Baik; S Rude; J R Wong; J H Postlethwait
Journal:  Genetics       Date:  1996-04       Impact factor: 4.562

4.  Statistical analysis of half-tetrads.

Authors:  H Zhao; T P Speed
Journal:  Genetics       Date:  1998-09       Impact factor: 4.562

5.  MHC-genotype of progeny influenced by parental infection.

Authors:  T Rülicke; M Chapuisat; F R Homberger; E Macas; C Wedekind
Journal:  Proc Biol Sci       Date:  1998-04-22       Impact factor: 5.349

6.  Multilocus analysis for gene-centromere mapping using first polar bodies and secondary oocytes.

Authors:  Y Da; V L Jarrell; T Wang; R L Fernando; M B Wheeler; H A Lewin
Journal:  Genetics       Date:  1995-02       Impact factor: 4.562

7.  Genetic mapping of the LMP2 proteasome subunit gene to the BoLA class IIb region.

Authors:  D Shalhevet; Y Da; J E Beever; M J van Eijk; R Ma; H A Lewin; H R Gaskins
Journal:  Immunogenetics       Date:  1995       Impact factor: 2.846

8.  Half tetrad analysis in alfalfa using multiple restriction fragment length polymorphism markers.

Authors:  S Tavoletti; E T Bingham; B S Yandell; F Veronesi; T C Osborn
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-01       Impact factor: 11.205

9.  A genomic clone containing a telomere array maps near the centromere of mouse chromosome 6.

Authors:  C H Yen; Y Matsuda; V M Chapman; R W Elliott
Journal:  Mamm Genome       Date:  1995-02       Impact factor: 2.957

10.  Mouse centromere mapping using oligonucleotide probes that detect variants of the minor satellite.

Authors:  D Kipling; H E Wilson; A R Mitchell; B A Taylor; H J Cooke
Journal:  Chromosoma       Date:  1994-03       Impact factor: 4.316
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