Literature DB >> 16390318

Increased dosage of the RUNX1/AML1 gene: a third mode of RUNX leukemia?

Motomi Osato1, Yoshiaki Ito.   

Abstract

RUNX1/AML1, located on chromosome 21, is a key factor in the generation and maintenance of hematopoietic stem cells and the gene most frequently implicated in human leukemias. Chromosome translocations and point mutations are well-documented genetic alterations in RUNX leukemia (also known as CBF leukemia). In addition, overdosage or overexpression of RUNX1 is suspected to be a third mode of RUNX1 involvement in leukemogenesis. The possibility that this mode might underlie Down syndrome-related leukemias caused by trisomy of chromosome 21 is discussed.

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Year:  2005        PMID： 16390318     DOI： 10.1615/critreveukargeneexpr.v15.i3.40

Source DB:  PubMed          Journal:  Crit Rev Eukaryot Gene Expr        ISSN： 1045-4403            Impact factor:   1.807


  8 in total

Review 1.  Down syndrome: the brain in trisomic mode.

Authors:  Mara Dierssen
Journal:  Nat Rev Neurosci       Date:  2012-12       Impact factor: 34.870

2.  CD74 is a novel transcription regulator.

Authors:  Naama Gil-Yarom; Lihi Radomir; Lital Sever; Matthias P Kramer; Hadas Lewinsky; Chamutal Bornstein; Ronnie Blecher-Gonen; Zohar Barnett-Itzhaki; Vita Mirkin; Gilgi Friedlander; Lev Shvidel; Yair Herishanu; Elias J Lolis; Shirly Becker-Herman; Ido Amit; Idit Shachar
Journal:  Proc Natl Acad Sci U S A       Date:  2016-12-28       Impact factor: 11.205

Review 3.  The RUNX family: developmental regulators in cancer.

Authors:  Yoshiaki Ito; Suk-Chul Bae; Linda Shyue Huey Chuang
Journal:  Nat Rev Cancer       Date:  2015-01-16       Impact factor: 60.716

4.  Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.

Authors:  Ya-Huei Kuo; Sayyed K Zaidi; Svetlana Gornostaeva; Toshihisa Komori; Gary S Stein; Lucio H Castilla
Journal:  Blood       Date:  2009-01-28       Impact factor: 22.113

5.  The use of mouse models for understanding the biology of down syndrome and aging.

Authors:  Guido N Vacano; Nathan Duval; David Patterson
Journal:  Curr Gerontol Geriatr Res       Date:  2012-02-23

6.  Characterization of the Runx gene family in a jawless vertebrate, the Japanese lamprey (Lethenteron japonicum).

Authors:  Giselle Sek Suan Nah; Boon-Hui Tay; Sydney Brenner; Motomi Osato; Byrappa Venkatesh
Journal:  PLoS One       Date:  2014-11-18       Impact factor: 3.240

7.  Expression and Prognosis Analyses of Runt-Related Transcription Factor Family in Human Leukemia.

Authors:  Cheng-Cao Sun; Shu-Jun Li; Zhen-Long Chen; Guang Li; Qian Zhang; De-Jia Li
Journal:  Mol Ther Oncolytics       Date:  2018-12-18       Impact factor: 7.200

8.  Runx family genes in a cartilaginous fish, the elephant shark (Callorhinchus milii).

Authors:  Giselle Sek Suan Nah; Zhi Wei Lim; Boon-Hui Tay; Motomi Osato; Byrappa Venkatesh
Journal:  PLoS One       Date:  2014-04-03       Impact factor: 3.240
  8 in total

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