Literature DB >> 25592647

The RUNX family: developmental regulators in cancer.

Yoshiaki Ito1, Suk-Chul Bae2, Linda Shyue Huey Chuang1.   

Abstract

RUNX proteins belong to a family of metazoan transcription factors that serve as master regulators of development. They are frequently deregulated in human cancers, indicating a prominent and, at times, paradoxical role in cancer pathogenesis. The contextual cues that direct RUNX function represent a fast-growing field in cancer research and could provide insights that are applicable to early cancer detection and treatment. This Review describes how RUNX proteins communicate with key signalling pathways during the multistep progression to malignancy; in particular, we highlight the emerging partnership of RUNX with p53 in cancer suppression.

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Year:  2015        PMID： 25592647     DOI： 10.1038/nrc3877

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  191 in total

1.  Distinct in vivo requirements for establishment versus maintenance of transcriptional repression.

Authors:  John C Wheeler; Christine VanderZwan; Xiaoti Xu; Deborah Swantek; W Daniel Tracey; J Peter Gergen
Journal:  Nat Genet       Date:  2002-07-29       Impact factor: 38.330

Review 2.  Structure and regulated expression of mammalian RUNX genes.

Authors:  Ditsa Levanon; Yoram Groner
Journal:  Oncogene       Date:  2004-05-24       Impact factor: 9.867

Review 3.  BET domain co-regulators in obesity, inflammation and cancer.

Authors:  Anna C Belkina; Gerald V Denis
Journal:  Nat Rev Cancer       Date:  2012-06-22       Impact factor: 60.716

4.  A full-length Cbfa1 gene product perturbs T-cell development and promotes lymphomagenesis in synergy with myc.

Authors:  F Vaillant; K Blyth; A Terry; M Bell; E R Cameron; J Neil; M Stewart
Journal:  Oncogene       Date:  1999-11-25       Impact factor: 9.867

5.  Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene.

Authors:  M Stewart; A Terry; M Hu; M O'Hara; K Blyth; E Baxter; E Cameron; D E Onions; J C Neil
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-05       Impact factor: 11.205

6.  Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.

Authors:  Yun-Hye Jin; Eun-Joo Jeon; Qing-Lin Li; Yong Hee Lee; Joong-Kook Choi; Wun-Jae Kim; Kwang-Youl Lee; Suk-Chul Bae
Journal:  J Biol Chem       Date:  2004-05-10       Impact factor: 5.157

Review 7.  Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia.

Authors:  Motomi Osato
Journal:  Oncogene       Date:  2004-05-24       Impact factor: 9.867

8.  Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.

Authors:  D Malkin; F P Li; L C Strong; J F Fraumeni; C E Nelson; D H Kim; J Kassel; M A Gryka; F Z Bischoff; M A Tainsky
Journal:  Science       Date:  1990-11-30       Impact factor: 47.728

9.  Stage-specific sensitivity to p53 restoration during lung cancer progression.

Authors:  David M Feldser; Kamena K Kostova; Monte M Winslow; Sarah E Taylor; Chris Cashman; Charles A Whittaker; Francisco J Sanchez-Rivera; Rebecca Resnick; Roderick Bronson; Michael T Hemann; Tyler Jacks
Journal:  Nature       Date:  2010-11-25       Impact factor: 49.962

10.  A role for RUNX3 in inflammation-induced expression of IL23A in gastric epithelial cells.

Authors:  Yit Teng Hor; Dominic Chih-Cheng Voon; Jason Kin Wai Koo; Huajing Wang; Wen Min Lau; Hassan Ashktorab; Shing Leng Chan; Yoshiaki Ito
Journal:  Cell Rep       Date:  2014-07-05       Impact factor: 9.423
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  158 in total

Review 1.  RUNX1-dependent mechanisms in biological control and dysregulation in cancer.

Authors:  Deli Hong; Andrew J Fritz; Jonathan A Gordon; Coralee E Tye; Joseph R Boyd; Kirsten M Tracy; Seth E Frietze; Frances E Carr; Jeffrey A Nickerson; Andre J Van Wijnen; Anthony N Imbalzano; Sayyed K Zaidi; Jane B Lian; Janet L Stein; Gary S Stein
Journal:  J Cell Physiol       Date:  2018-12-04       Impact factor: 6.384

Review 2.  The RUNX complex: reaching beyond haematopoiesis into immunity.

Authors:  Dominic Chih-Cheng Voon; Yit Teng Hor; Yoshiaki Ito
Journal:  Immunology       Date:  2015-10-25       Impact factor: 7.397

3.  Runx2-I is an Early Regulator of Epithelial-Mesenchymal Cell Transition in the Chick Embryo.

Authors:  Andre L P Tavares; Jessie A Brown; Emily C Ulrich; Katerina Dvorak; Raymond B Runyan
Journal:  Dev Dyn       Date:  2017-07-19       Impact factor: 3.780

4.  Super-enhancers for RUNX3 are required for cell proliferation in EBV-infected B cell lines.

Authors:  Hiroki Hosoi; Akiko Niibori-Nambu; Giselle Sek Suan Nah; Avinash Govind Bahirvani; Michelle Meng Huang Mok; Takaomi Sanda; Alan Prem Kumar; Daniel G Tenen; Yoshiaki Ito; Takashi Sonoki; Motomi Osato
Journal:  Gene       Date:  2021-01-12       Impact factor: 3.688

5.  The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1.

Authors:  Taishi Yonezawa; Hirotaka Takahashi; Shiori Shikata; Xiaoxiao Liu; Moe Tamura; Shuhei Asada; Tsuyoshi Fukushima; Tomofusa Fukuyama; Yosuke Tanaka; Tatsuya Sawasaki; Toshio Kitamura; Susumu Goyama
Journal:  J Biol Chem       Date:  2017-05-23       Impact factor: 5.157

Review 6.  Lineage factors and differentiation states in lung cancer progression.

Authors:  W K C Cheung; D X Nguyen
Journal:  Oncogene       Date:  2015-03-30       Impact factor: 9.867

7.  Aurora kinase and RUNX: Reaching beyond transcription.

Authors:  Linda Shyue Huey Chuang; Vaidehi Krishnan; Yoshiaki Ito
Journal:  Cell Cycle       Date:  2016-08-05       Impact factor: 4.534

8.  Expression levels of the runt-related transcription factor 1 and 3 genes in the development of acute myeloid leukemia.

Authors:  Adrian Krygier; Dagmara Szmajda; Marta Żebrowska; Agnieszka Jeleń; Ewa Balcerczak
Journal:  Oncol Lett       Date:  2018-03-01       Impact factor: 2.967

9.  Runt-related Transcription Factor 1 (RUNX1) Binds to p50 in Macrophages and Enhances TLR4-triggered Inflammation and Septic Shock.

Authors:  Mao-Cai Luo; Si-Yuan Zhou; Dan-Ying Feng; Jun Xiao; Wei-Yun Li; Chun-Di Xu; Hong-Yan Wang; Tong Zhou
Journal:  J Biol Chem       Date:  2016-08-29       Impact factor: 5.157

10.  Tcf1 and Lef1 pack their own HDAC.

Authors:  Charles P Ng; Dan R Littman
Journal:  Nat Immunol       Date:  2016-05-19       Impact factor: 25.606
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