| Literature DB >> 28031488 |
Naama Gil-Yarom1, Lihi Radomir1, Lital Sever1, Matthias P Kramer1, Hadas Lewinsky1, Chamutal Bornstein1, Ronnie Blecher-Gonen1, Zohar Barnett-Itzhaki1, Vita Mirkin2, Gilgi Friedlander3, Lev Shvidel2, Yair Herishanu4, Elias J Lolis5, Shirly Becker-Herman1, Ido Amit1, Idit Shachar6.
Abstract
CD74 is a cell-surface receptor for the cytokine macrophage migration inhibitory factor. Macrophage migration inhibitory factor binding to CD74 induces its intramembrane cleavage and the release of its cytosolic intracellular domain (CD74-ICD), which regulates cell survival. In the present study, we characterized the transcriptional activity of CD74-ICD in chronic lymphocytic B cells. We show that following CD74 activation, CD74-ICD interacts with the transcription factors RUNX (Runt related transcription factor) and NF-κB and binds to proximal and distal regulatory sites enriched for genes involved in apoptosis, immune response, and cell migration. This process leads to regulation of expression of these genes. Our results suggest that identifying targets of CD74 will help in understanding of essential pathways regulating B-cell survival in health and disease.Entities:
Keywords: CD74; CLL; NF-κB; RUNX; transcription
Year: 2016 PMID： 28031488 PMCID： PMC5255621 DOI： 10.1073/pnas.1612195114
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205