| Literature DB >> 16385453 |
Anthony L Hinrichs1, Jen C Wang, Bernd Bufe, Jennifer M Kwon, John Budde, Rebecca Allen, Sarah Bertelsen, Whitney Evans, Danielle Dick, John Rice, Tatiana Foroud, John Nurnberger, Jay A Tischfield, Samuel Kuperman, Raymond Crowe, Victor Hesselbrock, Marc Schuckit, Laura Almasy, Bernice Porjesz, Howard J Edenberg, Henri Begleiter, Wolfgang Meyerhof, Laura J Bierut, Alison M Goate.
Abstract
A coding single-nucleotide polymorphism (cSNP), K172N, in hTAS2R16, a gene encoding a taste receptor for bitter beta -glucopyranosides, shows significant association with alcohol dependence (P = .00018). This gene is located on chromosome 7q in a region reported elsewhere to exhibit linkage with alcohol dependence. The SNP is located in the putative ligand-binding domain and is associated with an increased sensitivity to many bitter beta -glucopyranosides in the presence of the N172 allele. Individuals with the ancestral allele K172 are at increased risk of alcohol dependence, regardless of ethnicity. However, this risk allele is uncommon in European Americans (minor-allele frequency [MAF] 0.6%), whereas 45% of African Americans carry the allele (MAF 26%), which makes it a much more significant risk factor in the African American population.Entities:
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Year: 2005 PMID： 16385453 PMCID： PMC1380207 DOI： 10.1086/499253
Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025