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Literature DB >> 16377705

In vivo and in vitro studies of antibiotic release from and bacterial growth inhibition by antibiotic-impregnated polymethylmethacrylate hip spacers.

Jens Kelm¹, Thilo Regitz, Eduard Schmitt, Werner Jung, Konstantinos Anagnostakos.

Abstract

The antimicrobial properties and the elution characteristics of gentamicin-vancomycin-loaded hip spacers were studied in vivo and in vitro. Vancomycin elution was greater than gentamicin elution. The antibiotic concentrations in vivo were less than those in vitro. Not dependent on implantation duration, growth inhibition by spacers in vitro was observed for 2 weeks. The reason for protracted wound healing cannot be insufficient antibiotic release.

Entities: Chemical

Mesh：

Substances：

Year: 2006 PMID： 16377705 PMCID： PMC1346773 DOI： 10.1128/AAC.50.1.332-335.2006

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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Authors: Yao Fu; Weiyuan John Kao
Journal: Expert Opin Drug Deliv Date: 2010-04 Impact factor: 6.648

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Journal: Arch Bone Jt Surg Date: 2020-01

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Authors: Matthew C Swearingen; Jeffrey F Granger; Anne Sullivan; Paul Stoodley
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Authors: Paolo Cherubino; Marco Puricelli; Fabio D'Angelo
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