PURPOSE: Local recurrence of rectal cancer occurs in a considerable group of patients who have undergone radical treatment for primary tumour. The treatment of choice is surgical resection but the prognosis remains poor, as a negative margin excision is possible in only a small subset of patients. A review of prognostic factors for locally recurrent rectal cancer (LRRC) after surgery is presented. METHODS: We systematically reviewed the literature for reports on prognostic factors after surgical excision of LRRC. These reports were identified through a review of the Medline database from 1982 to 2004. RESULTS: This review highlights the most important prognostic factors for LRRC patients treated with surgery. Data are grouped on the basis of the prognostic factors investigated. CONCLUSIONS: R0 resection seems to be the only reliable prognostic factor; however, symptoms, pre-operative CEA doubling time, performance status and pre-operative radiotherapy can help patient selection before surgery. The results of this review provide the basis for improved outcome, aiming to assess patients who would benefit from reoperation.
PURPOSE: Local recurrence of rectal cancer occurs in a considerable group of patients who have undergone radical treatment for primary tumour. The treatment of choice is surgical resection but the prognosis remains poor, as a negative margin excision is possible in only a small subset of patients. A review of prognostic factors for locally recurrent rectal cancer (LRRC) after surgery is presented. METHODS: We systematically reviewed the literature for reports on prognostic factors after surgical excision of LRRC. These reports were identified through a review of the Medline database from 1982 to 2004. RESULTS: This review highlights the most important prognostic factors for LRRC patients treated with surgery. Data are grouped on the basis of the prognostic factors investigated. CONCLUSIONS: R0 resection seems to be the only reliable prognostic factor; however, symptoms, pre-operative CEA doubling time, performance status and pre-operative radiotherapy can help patient selection before surgery. The results of this review provide the basis for improved outcome, aiming to assess patients who would benefit from reoperation.
Authors: Timothy F Donahue; Bernard H Bochner; John P Sfakianos; Matthew Kent; Melanie Bernstein; William M Hilton; Eugene K Cha; Alyssa M Yee; Guido Dalbagni; Hebert A Vargas Journal: J Urol Date: 2013-12-30 Impact factor: 7.450
Authors: Y Nancy You; Halim Habiba; George J Chang; Miguel A Rodriguez-bigas; John M Skibber Journal: Ann Surg Oncol Date: 2010-12-04 Impact factor: 5.344
Authors: M Kruschewski; M Ciurea; S Lipka; S Daum; L Moser; B Meyer; J Gröne; J Budczies; H J Buhr Journal: Langenbecks Arch Surg Date: 2012-06-28 Impact factor: 3.445
Authors: Y N You; J M Skibber; C-Y Hu; C H Crane; P Das; E S Kopetz; C Eng; B W Feig; M A Rodriguez-Bigas; G J Chang Journal: Br J Surg Date: 2016-03-02 Impact factor: 6.939