Literature DB >> 16369041

A PE protein expressed by Mycobacterium avium is an effective T-cell immunogen.

Marcela Parra1, Nathalie Cadieux, Thames Pickett, Veerabadran Dheenadhayalan, Michael J Brennan.   

Abstract

Infection of mice with Mycobacterium avium or immunization with a novel PE gene expressed by M. avium (MaPE) showed that a dominant T-cell immune response was elicited. Immunization with an MaPE DNA vaccine protected mice against an aerosol challenge with Mycobacterium tuberculosis, suggesting that mycobacteria express PE antigens with cross-protective T-cell epitopes.

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Year:  2006        PMID： 16369041      PMCID： PMC1346660          DOI： 10.1128/IAI.74.1.786-789.2006

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  16 in total

Review 1.  The PE multigene family: a 'molecular mantra' for mycobacteria.

Authors:  Michael J Brennan; Giovanni Delogu
Journal:  Trends Microbiol       Date:  2002-05       Impact factor: 17.079

2.  Microarray analysis of the Mycobacterium tuberculosis transcriptional response to the acidic conditions found in phagosomes.

Authors:  Mark A Fisher; Bonnie B Plikaytis; Thomas M Shinnick
Journal:  J Bacteriol       Date:  2002-07       Impact factor: 3.490

3.  Expression of the PE_PGRS 33 protein in Mycobacterium smegmatis triggers necrosis in macrophages and enhanced mycobacterial survival.

Authors:  Veerabadran Dheenadhayalan; Giovanni Delogu; Michael J Brennan
Journal:  Microbes Infect       Date:  2005-09-12       Impact factor: 2.700

Review 4.  Genomics of Mycobacterium bovis.

Authors:  S V Gordon; K Eiglmeier; T Garnier; R Brosch; J Parkhill; B Barrell; S T Cole; R G Hewinson
Journal:  Tuberculosis (Edinb)       Date:  2001       Impact factor: 3.131

5.  DNA vaccine combinations expressing either tissue plasminogen activator signal sequence fusion proteins or ubiquitin-conjugated antigens induce sustained protective immunity in a mouse model of pulmonary tuberculosis.

Authors:  Giovanni Delogu; Amy Li; Charlene Repique; Frank Collins; Sheldon L Morris
Journal:  Infect Immun       Date:  2002-01       Impact factor: 3.441

6.  Immunological characterization of antigens encoded by the RD1 region of the Mycobacterium tuberculosis genome.

Authors:  P N Brusasca; R Colangeli; K P Lyashchenko; X Zhao; M Vogelstein; J S Spencer; D N McMurray; M L Gennaro
Journal:  Scand J Immunol       Date:  2001-11       Impact factor: 3.487

7.  Identification of novel Mycobacterium tuberculosis antigens with potential as diagnostic reagents or subunit vaccine candidates by comparative genomics.

Authors:  P J Cockle; S V Gordon; A Lalvani; B M Buddle; R G Hewinson; H M Vordermeier
Journal:  Infect Immun       Date:  2002-12       Impact factor: 3.441

8.  Evidence that mycobacterial PE_PGRS proteins are cell surface constituents that influence interactions with other cells.

Authors:  M J Brennan; G Delogu; Y Chen; S Bardarov; J Kriakov; M Alavi; W R Jacobs
Journal:  Infect Immun       Date:  2001-12       Impact factor: 3.441

9.  Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.

Authors:  R D Fleischmann; D Alland; J A Eisen; L Carpenter; O White; J Peterson; R DeBoy; R Dodson; M Gwinn; D Haft; E Hickey; J F Kolonay; W C Nelson; L A Umayam; M Ermolaeva; S L Salzberg; A Delcher; T Utterback; J Weidman; H Khouri; J Gill; A Mikula; W Bishai; W R Jacobs; J C Venter; C M Fraser
Journal:  J Bacteriol       Date:  2002-10       Impact factor: 3.490

10.  ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response.

Authors:  G Marcela Rodriguez; Martin I Voskuil; Benjamin Gold; Gary K Schoolnik; Issar Smith
Journal:  Infect Immun       Date:  2002-07       Impact factor: 3.441
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  10 in total

1.  The Mycobacterium avium ESX-5 PPE protein, PPE25-MAV, interacts with an ESAT-6 family Protein, MAV_2921, and localizes to the bacterial surface.

Authors:  Michael McNamara; Lia Danelishvili; Luiz E Bermudez
Journal:  Microb Pathog       Date:  2012-01-15       Impact factor: 3.738

2.  Specific and randomly derived immunoactive peptide mimotopes of mycobacterial antigens.

Authors:  Archna Sharma; Abhik Saha; Surajit Bhattacharjee; Subrata Majumdar; Sujoy K Das Gupta
Journal:  Clin Vaccine Immunol       Date:  2006-08-17

3.  Immunogenicity and reactivity of novel Mycobacterium avium subsp. paratuberculosis PPE MAP1152 and conserved MAP1156 proteins with sera from experimentally and naturally infected animals.

Authors:  John P Bannantine; Avery L Paulson; Ofelia Chacon; Robert J Fenton; Denise K Zinniel; David S McVey; David R Smith; Charles J Czuprynski; Raúl G Barletta
Journal:  Clin Vaccine Immunol       Date:  2010-11-17

4.  Coexpression of PPE 34.9 Antigen of Mycobacterium avium subsp. Paratuberculosis with Murine Interferon Gamma in HeLa Cell Line and Study of Their Immunogenicity in Murine Model.

Authors:  Rajib Deb; P P Goswami
Journal:  Biotechnol Res Int       Date:  2011-02-10

5.  The transcriptional regulator Rv0485 modulates the expression of a pe and ppe gene pair and is required for Mycobacterium tuberculosis virulence.

Authors:  Rachael M Goldstone; Sunali D Goonesekera; Barry R Bloom; Samantha L Sampson
Journal:  Infect Immun       Date:  2009-08-03       Impact factor: 3.441

Review 6.  Mycobacterial PE/PPE proteins at the host-pathogen interface.

Authors:  Samantha L Sampson
Journal:  Clin Dev Immunol       Date:  2011-01-26

7.  Expression of a Gene Encoding 34.9 kDa PPE Antigen of Mycobacterium avium subsp. paratuberculosis in E. coli.

Authors:  Rajib Deb; P P Goswami
Journal:  Mol Biol Int       Date:  2010-05-18

8.  Mycobacterium tuberculosis Co-operonic PE32/PPE65 Proteins Alter Host Immune Responses by Hampering Th1 Response.

Authors:  Mohd Khubaib; Javaid A Sheikh; Saurabh Pandey; Battu Srikanth; Manish Bhuwan; Nooruddin Khan; Seyed E Hasnain; Nasreen Z Ehtesham
Journal:  Front Microbiol       Date:  2016-05-17       Impact factor: 5.640

9.  Expression and purification of a gene encoding a 9.7 kDa PE protein of Mycobacterium avium subsp. paratuberculosis.

Authors:  S Chandra Sekar; P P Goswami; R Deb
Journal:  3 Biotech       Date:  2016-09-15       Impact factor: 2.406

Review 10.  The Enigmatic PE/PPE Multigene Family of Mycobacteria and Tuberculosis Vaccination.

Authors:  Michael J Brennan
Journal:  Infect Immun       Date:  2017-05-23       Impact factor: 3.441
  10 in total

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