Literature DB >> 11973159

The PE multigene family: a 'molecular mantra' for mycobacteria.

Michael J Brennan1, Giovanni Delogu.   

Abstract

The PE multigene family of Mycobacterium tuberculosis is remarkable in that it is composed of approximately 100 highly homologous genes that are found only in mycobacteria. Early evidence suggests that proteins encoded by certain members of this gene family could be present in the mycobacterial cell wall, impact antigen-presentation pathways and the ensuing host immune responses, and also provide a mechanism for generating antigenic diversity in mycobacteria.

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Year:  2002        PMID： 11973159     DOI： 10.1016/s0966-842x(02)02335-1

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  83 in total

1.  Mycobacterium tuberculosis PPE60 antigen drives Th1/Th17 responses via Toll-like receptor 2-dependent maturation of dendritic cells.

Authors:  Haibo Su; Zhen Zhang; Zijian Liu; Baozhou Peng; Cong Kong; Honghai Wang; Zhi Zhang; Ying Xu
Journal:  J Biol Chem       Date:  2018-05-08       Impact factor: 5.157

2.  In vitro analysis of rates and spectra of mutations in a polymorphic region of the Rv0746 PE_PGRS gene of Mycobacterium tuberculosis.

Authors:  Edith E Machowski; Samantha Barichievy; Burkhard Springer; Steven I Durbach; Valerie Mizrahi
Journal:  J Bacteriol       Date:  2006-12-15       Impact factor: 3.490

3.  Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis.

Authors:  Michael Strong; Michael R Sawaya; Shuishu Wang; Martin Phillips; Duilio Cascio; David Eisenberg
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-11       Impact factor: 11.205

4.  Functional role of the PE domain and immunogenicity of the Mycobacterium tuberculosis triacylglycerol hydrolase LipY.

Authors:  Kanhu C Mishra; Chantal de Chastellier; Yeddula Narayana; Pablo Bifani; Alistair K Brown; Gurdyal S Besra; Vishwa M Katoch; Beenu Joshi; Kithiganahalli N Balaji; Laurent Kremer
Journal:  Infect Immun       Date:  2007-10-15       Impact factor: 3.441

5.  A PE protein expressed by Mycobacterium avium is an effective T-cell immunogen.

Authors:  Marcela Parra; Nathalie Cadieux; Thames Pickett; Veerabadran Dheenadhayalan; Michael J Brennan
Journal:  Infect Immun       Date:  2006-01       Impact factor: 3.441

6.  Variation of the Mycobacterium tuberculosis PE_PGRS 33 gene among clinical isolates.

Authors:  Sarah Talarico; M Donald Cave; Carl F Marrs; Betsy Foxman; Lixin Zhang; Zhenhua Yang
Journal:  J Clin Microbiol       Date:  2005-10       Impact factor: 5.948

7.  Mycobacterium tuberculosis of the RDRio genotype is the predominant cause of tuberculosis and associated with multidrug resistance in Porto Alegre City, South Brazil.

Authors:  Elis Regina Dalla Costa; Luiz Claudio Oliveira Lazzarini; Paulo Fernado Perizzolo; Chyntia Acosta Díaz; Fernanda S Spies; Lucas Laux Costa; Andrezza W Ribeiro; Caroline Barroco; Sandra Jungblut Schuh; Marcia Aparecida da Silva Pereira; Claudia F Dias; Harrison M Gomes; Gisela Unis; Arnaldo Zaha; Pedro E Almeida da Silva; Philip N Suffys; Maria L R Rossetti
Journal:  J Clin Microbiol       Date:  2013-01-16       Impact factor: 5.948

8.  Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47.

Authors:  Neeraj K Saini; Andres Baena; Tony W Ng; Manjunatha M Venkataswamy; Steven C Kennedy; Shajo Kunnath-Velayudhan; Leandro J Carreño; Jiayong Xu; John Chan; Michelle H Larsen; William R Jacobs; Steven A Porcelli
Journal:  Nat Microbiol       Date:  2016-08-15       Impact factor: 17.745

9.  Frequent homologous recombination events in Mycobacterium tuberculosis PE/PPE multigene families: potential role in antigenic variability.

Authors:  Anis Karboul; Alberto Mazza; Nicolaas C Gey van Pittius; John L Ho; Roland Brousseau; Helmi Mardassi
Journal:  J Bacteriol       Date:  2008-09-26       Impact factor: 3.490

10.  Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved.

Authors:  Iñaki Comas; Jaidip Chakravartti; Peter M Small; James Galagan; Stefan Niemann; Kristin Kremer; Joel D Ernst; Sebastien Gagneux
Journal:  Nat Genet       Date:  2010-05-23       Impact factor: 38.330
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