| Literature DB >> 16330130 |
Robert M Moriarty1, Simonida Grubjesic, Bhushan C Surve, Susantha N Chandersekera, Om Prakash, Rajesh Naithani.
Abstract
A facile and efficient approach to the synthesis of prenylated flavonoids as potential chemopreventive agents has been described. This features the synthesis of prenyl halide, prenylation of p-hydroxybenzaldehyde, formation of prenylated polyhydroxychalcone and cyclization of prenylated polyhydroxychalcone to flavanones (15) and (16), and flavonol (17) starting from isoprene (1). The structures of all three compounds have been characterized by NMR, IR and mass spectroscopy.Entities:
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Year: 2005 PMID： 16330130 DOI： 10.1016/j.ejmech.2005.09.008
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514