Literature DB >> 16327784

Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders.

Mirella Dapretto1, Mari S Davies, Jennifer H Pfeifer, Ashley A Scott, Marian Sigman, Susan Y Bookheimer, Marco Iacoboni.   

Abstract

To examine mirror neuron abnormalities in autism, high-functioning children with autism and matched controls underwent fMRI while imitating and observing emotional expressions. Although both groups performed the tasks equally well, children with autism showed no mirror neuron activity in the inferior frontal gyrus (pars opercularis). Notably, activity in this area was inversely related to symptom severity in the social domain, suggesting that a dysfunctional 'mirror neuron system' may underlie the social deficits observed in autism.

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Mesh：

Year:  2005        PMID： 16327784      PMCID： PMC3713227          DOI： 10.1038/nn1611

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  14 in total

Review 1.  Imitation, mirror neurons and autism.

Authors:  J H Williams; A Whiten; T Suddendorf; D I Perrett
Journal:  Neurosci Biobehav Rev       Date:  2001-06       Impact factor: 8.989

2.  Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas.

Authors:  Laurie Carr; Marco Iacoboni; Marie-Charlotte Dubeau; John C Mazziotta; Gian Luigi Lenzi
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-07       Impact factor: 11.205

3.  Activation of the fusiform gyrus when individuals with autism spectrum disorder view faces.

Authors:  Nouchine Hadjikhani; Robert M Joseph; Josh Snyder; Christopher F Chabris; Jill Clark; Shelly Steele; Lauren McGrath; Mark Vangel; Itzhak Aharon; Eric Feczko; Gordon J Harris; Helen Tager-Flusberg
Journal:  Neuroimage       Date:  2004-07       Impact factor: 6.556

4.  EEG evidence for mirror neuron dysfunction in autism spectrum disorders.

Authors:  Lindsay M Oberman; Edward M Hubbard; Joseph P McCleery; Eric L Altschuler; Vilayanur S Ramachandran; Jaime A Pineda
Journal:  Brain Res Cogn Brain Res       Date:  2005-07

5.  Cortical mechanisms of human imitation.

Authors:  M Iacoboni; R P Woods; M Brass; H Bekkering; J C Mazziotta; G Rizzolatti
Journal:  Science       Date:  1999-12-24       Impact factor: 47.728

6.  The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism.

Authors:  C Lord; S Risi; L Lambrecht; E H Cook; B L Leventhal; P C DiLavore; A Pickles; M Rutter
Journal:  J Autism Dev Disord       Date:  2000-06

7.  Actions or hand-object interactions? Human inferior frontal cortex and action observation.

Authors:  Scott H Johnson-Frey; Farah R Maloof; Roger Newman-Norlund; Chloe Farrer; Souheil Inati; Scott T Grafton
Journal:  Neuron       Date:  2003-09-11       Impact factor: 17.173

8.  Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders.

Authors:  C Lord; M Rutter; A Le Couteur
Journal:  J Autism Dev Disord       Date:  1994-10

Review 9.  The mirror-neuron system.

Authors:  Giacomo Rizzolatti; Laila Craighero
Journal:  Annu Rev Neurosci       Date:  2004       Impact factor: 12.449

10.  Functional imaging of face and hand imitation: towards a motor theory of empathy.

Authors:  Kenneth R Leslie; Scott H Johnson-Frey; Scott T Grafton
Journal:  Neuroimage       Date:  2004-02       Impact factor: 6.556
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  394 in total

Review 1.  Autism spectrum disorder: does neuroimaging support the DSM-5 proposal for a symptom dyad? A systematic review of functional magnetic resonance imaging and diffusion tensor imaging studies.

Authors:  Laura Pina-Camacho; Sonia Villero; David Fraguas; Leticia Boada; Joost Janssen; Francisco J Navas-Sánchez; Maria Mayoral; Cloe Llorente; Celso Arango; Mara Parellada
Journal:  J Autism Dev Disord       Date:  2012-07

2.  Developmental changes in mu suppression to observed and executed actions in autism spectrum disorders.

Authors:  Lindsay M Oberman; Joseph P McCleery; Edward M Hubbard; Raphael Bernier; Jan R Wiersema; Ruth Raymaekers; Jaime A Pineda
Journal:  Soc Cogn Affect Neurosci       Date:  2012-02-01       Impact factor: 3.436

3.  The neuroscience of empathy: progress, pitfalls and promise.

Authors:  Jamil Zaki; Kevin N Ochsner; Kevin Ochsner
Journal:  Nat Neurosci       Date:  2012-04-15       Impact factor: 24.884

Review 4.  Facial emotion recognition in autism spectrum disorders: a review of behavioral and neuroimaging studies.

Authors:  Madeline B Harms; Alex Martin; Gregory L Wallace
Journal:  Neuropsychol Rev       Date:  2010-09-01       Impact factor: 7.444

Review 5.  From music making to speaking: engaging the mirror neuron system in autism.

Authors:  Catherine Y Wan; Krystal Demaine; Lauryn Zipse; Andrea Norton; Gottfried Schlaug
Journal:  Brain Res Bull       Date:  2010-04-28       Impact factor: 4.077

Review 6.  Stimulus overselectivity four decades later: a review of the literature and its implications for current research in autism spectrum disorder.

Authors:  Bertram O Ploog
Journal:  J Autism Dev Disord       Date:  2010-11

7.  Aberrant striatal functional connectivity in children with autism.

Authors:  Adriana Di Martino; Clare Kelly; Rebecca Grzadzinski; Xi-Nian Zuo; Maarten Mennes; Maria Angeles Mairena; Catherine Lord; F Xavier Castellanos; Michael P Milham
Journal:  Biol Psychiatry       Date:  2010-12-31       Impact factor: 13.382

8.  Dissociation between key processes of social cognition in autism: impaired mentalizing but intact sense of agency.

Authors:  Nicole David; Astrid Gawronski; Natacha S Santos; Wolfgang Huff; Fritz-Georg Lehnhardt; Albert Newen; Kai Vogeley
Journal:  J Autism Dev Disord       Date:  2007-08-21

9.  Neurofeedback training produces normalization in behavioural and electrophysiological measures of high-functioning autism.

Authors:  Jaime A Pineda; Karen Carrasco; Mike Datko; Steven Pillen; Matt Schalles
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2014-04-28       Impact factor: 6.237

10.  Autism and the mirror neuron system: insights from learning and teaching.

Authors:  Giacomo Vivanti; Sally J Rogers
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2014-04-28       Impact factor: 6.237
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