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Literature DB >> 16322510

Chromosomal fragmentation is the major consequence of the rdgB defect in Escherichia coli.

Abstract

The rdgB mutants depend on recombinational repair of double-strand breaks. To assess other consequences of rdgB inactivation in Escherichia coli, we isolated RdgB-dependent mutants. All transposon inserts making cells dependent on RdgB inactivate genes of double-strand break repair, indicating that chromosomal fragmentation is the major consequence of RdgB inactivation.

Entities: Gene Species

Mesh：

Substances：

Year: 2005 PMID： 16322510 PMCID： PMC1456232 DOI： 10.1534/genetics.105.051144

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

16 in total

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Journal: Biochemistry Date: 1992-11-17 Impact factor: 3.162

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Journal: J Bacteriol Date: 1991-02 Impact factor: 3.490

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Authors: J Clyman; R P Cunningham
Journal: J Bacteriol Date: 1987-09 Impact factor: 3.490

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Authors: R J Reid; P Fiorani; M Sugawara; M A Bjornsti
Journal: Proc Natl Acad Sci U S A Date: 1999-09-28 Impact factor: 11.205

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Journal: J Bacteriol Date: 1982-07 Impact factor: 3.490

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Authors: Elena A Kouzminova; Ella Rotman; Lee Macomber; Jian Zhang; Andrei Kuzminov
Journal: Proc Natl Acad Sci U S A Date: 2004-11-05 Impact factor: 11.205

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Review 10. Nucleoside and nucleobase analog mutagens.

Authors: K Negishi; T Bessho; H Hayatsu
Journal: Mutat Res Date: 1994-12 Impact factor: 2.433

16 in total

1. Functional study of the P32T ITPA variant associated with drug sensitivity in humans.

Authors: Elena I Stepchenkova; Elena R Tarakhovskaya; Kathryn Spitler; Christin Frahm; Miriam R Menezes; Peter D Simone; Carol Kolar; Luis A Marky; Gloria E O Borgstahl; Youri I Pavlov
Journal: J Mol Biol Date: 2009-07-23 Impact factor: 5.469

2. Synthetic lethality with the dut defect in Escherichia coli reveals layers of DNA damage of increasing complexity due to uracil incorporation.

Authors: Helen Ting; Elena A Kouzminova; Andrei Kuzminov
Journal: J Bacteriol Date: 2008-06-27 Impact factor: 3.490

Chromosomal fragmentation is the major consequence of the rdgB defect in Escherichia coli.

1. A repair system for 8-oxo-7,8-dihydrodeoxyguanine.

2. Suppression of the defects in rdgB mutants of Escherichia coli K-12 by the cloned purA gene.

Review 3. The MutT proteins or "Nudix" hydrolases, a family of versatile, widely distributed, "housecleaning" enzymes.

4. Escherichia coli K-12 mutants in which viability is dependent on recA function.

5. CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage.

6. Interaction of deoxyinosine 3'-endonuclease from Escherichia coli with DNA containing deoxyinosine.

7. Role of exonuclease III in the base excision repair of uracil-containing DNA.

8. RecA-dependent mutants in Escherichia coli reveal strategies to avoid chromosomal fragmentation.

9. Purification and characterization of a novel deoxyinosine-specific enzyme, deoxyinosine 3' endonuclease, from Escherichia coli.

Review 10. Nucleoside and nucleobase analog mutagens.

1. Functional study of the P32T ITPA variant associated with drug sensitivity in humans.

2. Synthetic lethality with the dut defect in Escherichia coli reveals layers of DNA damage of increasing complexity due to uracil incorporation.

Review 3. Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools.

4. Hypoxanthine incorporation is nonmutagenic in Escherichia coli.

5. Replication fork inhibition in seqA mutants of Escherichia coli triggers replication fork breakage.

6. Structure of the orthorhombic form of human inosine triphosphate pyrophosphatase.

7. Iron and zinc binding activity of Escherichia coli topoisomerase I homolog YrdD.

8. Elevated Levels of DNA Strand Breaks Induced by a Base Analog in the Human Cell Line with the P32T ITPA Variant.

9. Production of clastogenic DNA precursors by the nucleotide metabolism in Escherichia coli.

10. Homologous Recombination-Experimental Systems, Analysis, and Significance.